Activated mesenchymal stem/stromal cells promote myeloid cell differentiation via CCL2/CCR2 signaling

Satoshi Yamazaki, Yo Mabuchi, Takaharu Kimura, Eriko Grace Suto, Daisuke Hisamatsu, Yuna Naraoka, Ayako Kondo, Yuzuki Azuma, Riko Kikuchi, Hidekazu Nishikii, Soji Morishita, Marito Araki, Norio Komatsu, Chihiro Akazawa

研究成果: ジャーナルへの寄稿学術論文査読


Myeloid cells, which originate from hematopoietic stem/progenitor cells (HSPCs), play a crucial role in mitigating infections. This study aimed to explore the impact of mesenchymal stem/stromal cells (MSCs) on the differentiation of HSPCs and progenitors through the C-C motif chemokine CCL2/CCR2 signaling pathway. Murine MSCs, identified as PDGFRα+Sca-1+ cells (PαS cells), were found to secrete CCL2, particularly in response to lipopolysaccharide stimulation. MSC-secreted CCL2 promoted the differentiation of granulocyte/macrophage progenitors into the myeloid lineage. MSC-derived CCL2 plays an important role in the early phase of myeloid cell differentiation in vivo. Single-cell RNA sequencing analysis confirmed that CCL2-mediated cell fate determination was also observed in human bone marrow cells. These findings provide valuable insights for investigating the in vivo effects of MSC transplantation.

ジャーナルStem Cell Reports
出版ステータス出版済み - 12-03-2024

All Science Journal Classification (ASJC) codes

  • 生化学
  • 遺伝学
  • 発生生物学
  • 細胞生物学


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