抄録
Myeloid cells, which originate from hematopoietic stem/progenitor cells (HSPCs), play a crucial role in mitigating infections. This study aimed to explore the impact of mesenchymal stem/stromal cells (MSCs) on the differentiation of HSPCs and progenitors through the C-C motif chemokine CCL2/CCR2 signaling pathway. Murine MSCs, identified as PDGFRα+Sca-1+ cells (PαS cells), were found to secrete CCL2, particularly in response to lipopolysaccharide stimulation. MSC-secreted CCL2 promoted the differentiation of granulocyte/macrophage progenitors into the myeloid lineage. MSC-derived CCL2 plays an important role in the early phase of myeloid cell differentiation in vivo. Single-cell RNA sequencing analysis confirmed that CCL2-mediated cell fate determination was also observed in human bone marrow cells. These findings provide valuable insights for investigating the in vivo effects of MSC transplantation.
本文言語 | 英語 |
---|---|
ページ(範囲) | 414-425 |
ページ数 | 12 |
ジャーナル | Stem Cell Reports |
巻 | 19 |
号 | 3 |
DOI | |
出版ステータス | 出版済み - 12-03-2024 |
All Science Journal Classification (ASJC) codes
- 生化学
- 遺伝学
- 発生生物学
- 細胞生物学