Activation of both dopamine D1 and D2 receptors necessary for amelioration of conditioned fear stress

Hiroyuki Kamei, Tsutomu Kameyama, Toshitaka Nabeshima

研究成果: Article

24 引用 (Scopus)

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Mice exhibited a marked suppression of motility when they were re-placed in the same environment in which they had previously received an electric footshock. This psychological stress-induced motor suppression, known as conditioned fear stress, was dose dependently attenuated by apomorphine, a non-selective dopamine receptor agonist. Combined treatment with the dopamine D1 receptor agonist, SKF 38393 (2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1-H-3-benzazepine), and the dopamine D2 receptor agonist, quinpirole, also synergistically attenuated the conditioned fear stress although, alone, neither SKF 38393 nor quinpirole did so at the doses used. The effects of apomorphine and of the coadministration of SKF 38393 and quinpirole on the conditioned fear stress were completely blocked by the dopamine D1 receptor antagonist, SCH 23390 (R-(+)-7-chloro-8-hy-droxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1 H-3-benzazepine), and by the dopamine D2 receptor antagonist, (-)-sulpiride. These results suggest that a dysfunction in the dopaminergic neuronal system is responsible for the conditioned fear stress, and that the activation of both dopamine D1 and D2 receptors is necessary to attenuate this stress-induced motor suppression.

元の言語English
ページ(範囲)229-233
ページ数5
ジャーナルEuropean Journal of Pharmacology
273
発行部数3
DOI
出版物ステータスPublished - 06-02-1995
外部発表Yes

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All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Cellular and Molecular Neuroscience

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