Activation of protein kinase C by non-phorbol tumor promoter, mezerein

Ryohei Miyake, Yasushi Tanaka, Terutaka Tsuda, Kozo Kaibuchi, Ushio Kikkawa, Yasutomi Nishizuka

研究成果: Article査読

118 被引用数 (Scopus)

抄録

Mezerein, classified as a second-stage tumor promoter, has no diacylglycerol-like structure in its molecule, but can activate protein kinase C both in vitro and in vivo. This non-phorbol diterpene competitively inhibits the specific binding of a radioactive tumor-promoting phorbol ester to the enzyme. It is suggestive that tumor-promoting phorbol esters and mezerein cause analogous changes in the membrane to activate protein kinase C, and utilize this protein kinase as a common receptive protein for tumor promotion.

本文言語English
ページ(範囲)649-656
ページ数8
ジャーナルBiochemical and Biophysical Research Communications
121
2
DOI
出版ステータスPublished - 15-06-1984
外部発表はい

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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