Activation of protein kinase C by non-phorbol tumor promoter, mezerein

Ryohei Miyake, Yasushi Tanaka, Terutaka Tsuda, Kozo Kaibuchi, Ushio Kikkawa, Yasutomi Nishizuka

研究成果: ジャーナルへの寄稿学術論文査読

125 被引用数 (Scopus)

抄録

Mezerein, classified as a second-stage tumor promoter, has no diacylglycerol-like structure in its molecule, but can activate protein kinase C both in vitro and in vivo. This non-phorbol diterpene competitively inhibits the specific binding of a radioactive tumor-promoting phorbol ester to the enzyme. It is suggestive that tumor-promoting phorbol esters and mezerein cause analogous changes in the membrane to activate protein kinase C, and utilize this protein kinase as a common receptive protein for tumor promotion.

本文言語英語
ページ(範囲)649-656
ページ数8
ジャーナルBiochemical and Biophysical Research Communications
121
2
DOI
出版ステータス出版済み - 15-06-1984
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

フィンガープリント

「Activation of protein kinase C by non-phorbol tumor promoter, mezerein」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル