Activation of the heart by donor brain death accelerates acute rejection after transplantation

M. J. Wilhelm, J. Pratschke, F. Beato, M. Taal, M. Kusaka, W. W. Hancock, N. L. Tilney

研究成果: Article査読

161 被引用数 (Scopus)

抄録

Background - Donor brain death upregulates expression of inflammatory mediators in the heart. It is hypothesized that these nonspecific changes trigger and amplify acute rejection in unmodified recipients compared with hearts from normal living donors. We examined the inflammatory and immunological consequences of gradual-onset donor brain death on cardiac allografts after tra nsplantation. Methods and Results - Functioning hearts were engrafted from normotensive donors after 6 hours of ventilatory support. Hearts from brain-dead rats (Fisher, F344) were rejected significantly earlier (mean ± SD, 9.3 ± 0.6 days) by their (Lewis) recipients than hearts from living donor controls (11.6 ± 0.7 days, P=0.03). The inflammatory response of such organs was accelerated, with rapid expression of cytokines, chemokines, and adhesion molecules and brisk infiltration of associated leukocyte populations. Upregulation of major histocompatibility class II antigens increased organ immuno genicity. Acute rejection evolved in hearts from brain-dead donors more intensely and at a significantly faster rate than in controls. Conclusions - Donor brain death is deleterious to transplanted hearts. The resultant upregulation of inflammatory factors provokes host immune mechanisms and accelerates the acute rejection process in unmodified hosts.

本文言語English
ページ(範囲)2426-2433
ページ数8
ジャーナルCirculation
102
19 SUPPL.
DOI
出版ステータスPublished - 07-11-2000
外部発表はい

All Science Journal Classification (ASJC) codes

  • 循環器および心血管医学
  • 生理学(医学)

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