TY - JOUR
T1 - Activin and activin receptor expression changes in liver regeneration in rat
AU - Takamura, Kazuhito
AU - Tsuchida, Kunihiro
AU - Miyake, Hidenori
AU - Tashiro, Seiki
AU - Sugino, Hiromu
PY - 2005/6/1
Y1 - 2005/6/1
N2 - Background. This study aimed to investigate regulatory mechanisms of hepatocyte proliferation by comparing liver regeneration of the remnant lobe after 70% partial hepatectomy (PH) and portal vein branch ligation (PBL) in rat. Methods. Expressions of activins βA, βC, and βE and their receptors were investigated after PH and PBL. The proliferating cell nuclear antigen (PCNA) labeling index was used to monitor hepatocyte proliferation. Results. The PCNA labeling index in the regenerative lobe of PBL rats reached a peak at 48 h, a delay of 24 h compared with the remnant lobe in PH rats. In the postoperative early stage, the expression of activin βA, βC, and βE mRNAs was stronger in PBL than PH. At 72 h the expression of activin receptor type IIA mRNA reached a peak in PH but was significantly lower in PBL. Conclusions. Hepatocyte proliferation, and the regulated expression of activins and their receptors, differs during liver regeneration after PH and PBL in the rat. Thus, regulation of activin signaling through receptors is one of the factors determining liver regeneration after PH and PBL.
AB - Background. This study aimed to investigate regulatory mechanisms of hepatocyte proliferation by comparing liver regeneration of the remnant lobe after 70% partial hepatectomy (PH) and portal vein branch ligation (PBL) in rat. Methods. Expressions of activins βA, βC, and βE and their receptors were investigated after PH and PBL. The proliferating cell nuclear antigen (PCNA) labeling index was used to monitor hepatocyte proliferation. Results. The PCNA labeling index in the regenerative lobe of PBL rats reached a peak at 48 h, a delay of 24 h compared with the remnant lobe in PH rats. In the postoperative early stage, the expression of activin βA, βC, and βE mRNAs was stronger in PBL than PH. At 72 h the expression of activin receptor type IIA mRNA reached a peak in PH but was significantly lower in PBL. Conclusions. Hepatocyte proliferation, and the regulated expression of activins and their receptors, differs during liver regeneration after PH and PBL in the rat. Thus, regulation of activin signaling through receptors is one of the factors determining liver regeneration after PH and PBL.
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U2 - 10.1016/j.jss.2005.01.002
DO - 10.1016/j.jss.2005.01.002
M3 - Article
C2 - 15916968
AN - SCOPUS:19444375906
SN - 0022-4804
VL - 126
SP - 3
EP - 11
JO - Journal of Surgical Research
JF - Journal of Surgical Research
IS - 1
ER -