Acute and chronic effects of pentobarbital in relation to postsynaptic GABA receptors: A study with muscimol

S. P. Sivam, T. Nabeshima, I. K. Ho

研究成果: Article査読

43 被引用数 (Scopus)

抄録

Muscimol, a GABA agonist, enhanced pentobarbital sleeping time in a dose‐dependent manner. The GABA antagonists such as bicuculline and picrotoxin, and the CNS stimulant such as pentylenetetrazol, inhibited pentobarbital sleeping time; however, all except picrotoxin produced less than 35% maximum inhibition. Picrotoxin, an agent which blocks the chloride ionophore of GABA‐receptor complex, exhibited a parallel dose‐response curve with respect to muscimol. Chronic administration of pentobarbital by pellet implantation induced tolerance as evidenced by decreased sleeping time; the tolerance receded gradually upon abrupt withdrawal. Muscimol enhanced pentobarbital sleeping time both in tolerant and withdrawal mice. Na+‐independent GABA‐receptor binding, using [3H]muscimol as a ligand, was increased after acute and chronic pentobarbital administration; withdrawal of the pentobarbital reversed the increase in receptor population. None of the treatments altered the affinity of [3H]muscimol binding. These results support the contention that pentobarbital (a) directly acts on the postsynaptic chloride ionophore and (b) augments GABA‐mediated postsynaptic effects. The functional significance of the increase in GABA receptor population after pentobarbital treatment is unclear.

本文言語English
ページ(範囲)37-47
ページ数11
ジャーナルJournal of Neuroscience Research
7
1
DOI
出版ステータスPublished - 1982
外部発表はい

All Science Journal Classification (ASJC) codes

  • 細胞および分子神経科学

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