Acute homeostatic responses to increased fat consumption in MCH1R knockout mice

Shinjae Chung, Timothy Wong, Hiroshi Nagasaki, Olivier Civelli

研究成果: ジャーナルへの寄稿学術論文査読

6 被引用数 (Scopus)

抄録

Melanin-concentrating hormone (MCH) is a hypothalamic neuropeptide which has been shown to regulate energy homeostasis. Using genetic knockout mice lacking the MCH1 receptor (MCH1R), we investigated how these mice adapt to metabolic changes caused by excessive caloric consumption. We show that the MCH system is one of the players mediating behavioral and metabolic responses upon increased caloric consumption. MCH1R knockout mice showed decreased tendency of food intake upon exposure to a high-fat diet. They also are resistant to gain weight upon high-fat diet by increasing fat metabolism. Therefore, the MCH system is important in regulating metabolic responses upon various environmental stimuli such as high-fat diet.

本文言語英語
ページ(範囲)459-463
ページ数5
ジャーナルJournal of Molecular Neuroscience
42
3
DOI
出版ステータス出版済み - 11-2010
外部発表はい

All Science Journal Classification (ASJC) codes

  • 細胞および分子神経科学

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