Acute Kidney Injury Induced by Antimicrobial Agents in the Elderly: Awareness and Mitigation Strategies

Fumihiro Mizokami, Tomohiro Mizuno

研究成果: ジャーナルへの寄稿学術論文査読

15 被引用数 (Scopus)

抄録

The use of antimicrobial agents has increased in recent years as treatments have diversified and resistant bacteria have appeared. With increased use of antimicrobial agents, elderly patients are prone to adverse drug reactions (ADRs) as a result of factors such as drug–drug interactions, polypharmacy, long-term use, and over- or under-dosage. In particular, elderly patients using antimicrobials are at increased risk to develop drug-induced acute kidney injury (AKI), which is the most common severe ADR in such patients. AKI is a serious problem that is associated with mortality amongst hospitalized patients. Antimicrobial-induced AKI can be classified into three different types: acute tubular necrosis (ATN), acute interstitial nephritis (AIN), and renal tubule lumen obstruction. AKI can generally be prevented by proper maintenance of fluid balance. To design dosage regimens that ensure efficient drug excretion via the kidney, it is necessary to accurately estimate renal function; however, the kidney undergoes age-dependent structural and functional alterations over time. Therefore, proper management of antimicrobial agents by an antimicrobial stewardship team may lead to decreased incidence of AKI. This article reviews antimicrobial-induced AKI and discusses potential strategies for increasing awareness of AKI and mitigating its clinical effects.

本文言語英語
ページ(範囲)1-12
ページ数12
ジャーナルDrugs and Aging
32
1
DOI
出版ステータス出版済み - 01-2014
外部発表はい

All Science Journal Classification (ASJC) codes

  • 老年医学
  • 薬理学(医学)

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