Acute kidney injury presenting a feature of leukemic infiltration during therapy for chronic myelogenous leukemia

Yukio Yuzawa, Waichi Sato, Tomohiro Masuda, Yuzuru Hamada, Miho Tatematsu, Yoshinari Yasuda, Takenori Ozaki, Isao Ito, Masashi Mizuno, Shoichi Maruyama, Yasuhiko Ito, Seiichi Matsuo

研究成果: Article査読

7 被引用数 (Scopus)

抄録

Chronic myelogenous leukemia (CML) is a myeloproliferative disease that originates in abnormal pluripo- tent bone marrow stem cells and it is consistently associated with the Philadelphia chromosome and/or BCR/ ABL fusion gene. Renal infiltration of leukemic cells is relatively rare in CML and is associated with renal impairment. We describe a patient who developed acute renal failure by tubulointerstitial nephropathy during treatment with imatinib mesylate for CML. The acute kidney injury was subsequently found to be due to direct leukemic infiltration. Treatment with hydroxycarbamide and prednisolone resulted in stabilization of the renal function for approximately 4 months. Leukemic infiltration into the kidney should always be considered when a patient with CML presents with renal impairment, regardless of the clinical stage, as the renal failure often responds well to chemotherapy.

本文言語English
ページ(範囲)1139-1142
ページ数4
ジャーナルInternal Medicine
49
12
DOI
出版ステータスPublished - 2010
外部発表はい

All Science Journal Classification (ASJC) codes

  • Internal Medicine

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