Acute phencyclidine induces aversion, but repeated phencyclidine induces preference in the place conditioning test in rats

Kiyoyuki Kitaichi, Yukihiro Noda, Takaaki Hasegawa, Hiroshi Furukawa, Toshitaka Nabeshima

研究成果: Article

29 引用 (Scopus)

抜粋

Phencyclidine (PCP) is a drug that has been widely abused in the past two decades. PCP produces place aversion, but not preference, in the place conditioning test. The present study examined PCP-induced place conditioning behavior in rats treated with PCP repeatedly. In naive rats, PCP (2-8 mg/kg i.p.) dose dependently produced place aversion, but did not produce any effect in rats treated with PCP (10 mg/kg i.p.) for 14 days, indicating that tolerance developed to PCP-induced place aversion on repeated PCP treatment. In rats treated with PCP (10 mg/kg i.p.) for 28 days, PCP (2-8 mg/kg i.p.) dose dependently produced place preference. These findings suggest that some changes in neuronal function induced by the repeated PCP treatment may play an important role in the addiction to this drug.

元の言語English
ページ(範囲)7-9
ページ数3
ジャーナルEuropean Journal of Pharmacology
318
発行部数1
DOI
出版物ステータスPublished - 27-12-1996
外部発表Yes

All Science Journal Classification (ASJC) codes

  • Pharmacology

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