TY - JOUR
T1 - Adherence of lyme disease spirochetes to rat lymphocytes
AU - Fumarola, Donato
AU - Cedola, M. Costanza
AU - Guanti, Ginevra
AU - Matsuura, Akihiro
AU - Uede, Toshimistu
AU - Jirillo, Emilio
PY - 1986
Y1 - 1986
N2 - In the present work, the capacity of Lyme disease (LD) Spirochetes to spontaneously adhere to rat lymphocytes has been evaluated. Borrelia organisms adhere to thymus, spleen, Payer's patches and peripheral blood lymphocytes in a higher frequency than that observed with Salmonella minnesota R345 (Rb) used as reference strain. Employing enriched splenic T and B cell populations, Spirochete binding to B lymphocytes is more elevated than that obtained with Salmonella, while similar percentage of T cells forms rosettes with both microorganisms. Taken together, these findings provide evidence for a novel mode of interaction between LD Spirochetes and host immune system.
AB - In the present work, the capacity of Lyme disease (LD) Spirochetes to spontaneously adhere to rat lymphocytes has been evaluated. Borrelia organisms adhere to thymus, spleen, Payer's patches and peripheral blood lymphocytes in a higher frequency than that observed with Salmonella minnesota R345 (Rb) used as reference strain. Employing enriched splenic T and B cell populations, Spirochete binding to B lymphocytes is more elevated than that obtained with Salmonella, while similar percentage of T cells forms rosettes with both microorganisms. Taken together, these findings provide evidence for a novel mode of interaction between LD Spirochetes and host immune system.
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U2 - 10.1016/S0176-6724(86)80117-1
DO - 10.1016/S0176-6724(86)80117-1
M3 - Article
C2 - 3495084
AN - SCOPUS:0022892519
SN - 0176-6724
VL - 263
SP - 146
EP - 150
JO - Zentralblatt fur Bakteriologie Mikrobiologie und Hygiene - Abt. 1 Orig. A
JF - Zentralblatt fur Bakteriologie Mikrobiologie und Hygiene - Abt. 1 Orig. A
IS - 1-2
ER -