@article{b1f31224a44e440db3f5b6d552d92aa3,
title = "Adipsin-dependent secretion of hepatocyte growth factor regulates the adipocyte-cancer stem cell interaction",
abstract = "Adipose tissue is a component of the tumor microenvironment and is involved in tumor progression. We have previously shown that adipokine adipsin (CFD) functions as an enhancer of tumor proliferation and cancer stem cell (CSC) properties in breast cancers. We established the Cfd-knockout (KO) mice and the mammary adipose tissue-derived stem cells (mADSCs) from them. Cfd-KO in mADSCs significantly reduced their ability to enhance tumorsphere formation of breast cancer patient-derived xenograft (PDX) cells, which was restored by the addition of Cfd in the culture medium. Hepatocyte growth factor (HGF) was expressed and secreted from mADSCs in a Cfd-dependent manner. HGF rescued the reduced ability of Cfd-KO mADSCs to promote tumorsphere formation in vitro and tumor formation in vivo by breast cancer PDX cells. These results suggest that HGF is a downstream effector of Cfd in mADSCs that enhances the CSC properties in breast cancers.",
author = "Masahiro Mizuno and Behnoush Khaledian and Masao Maeda and Takanori Hayashi and Seiya Mizuno and Eiji Munetsuna and Takashi Watanabe and Seishi Kono and Seiji Okada and Motoshi Suzuki and Shintaro Takao and Hironobu Minami and Naoya Asai and Fumihiro Sugiyama and Satoru Takahashi and Yohei Shimono",
note = "Funding Information: Funding: This work was supported by: (1) grants-in-aid from the Japan Society for the Promotion of Science (JSPS KAKENHI) (18K07231, 21H02769 and Japan-Belgium Research Cooperative Program to Y.S.; 19K09106 to M.M. (Masao Maeda)); (2) the Princess Takamatsu Cancer Research Fund (to Y.S.); (3) the Fujita Health University (to Y.S.); (4) an extramural collaborative research grant of Cancer Research Institute, Kanazawa University (to Y.S.); (5) the Promotion and Mutual Aid Corporation for Private Schools of Japan (to Y.S.); (6) Chubu Regional Consortium for Advanced Medicine (C-CAM) (to Y.S.). The funders had no role in study design, data collection, and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2021",
month = aug,
day = "2",
doi = "10.3390/cancers13164238",
language = "English",
volume = "13",
journal = "Cancers",
issn = "2072-6694",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "16",
}