Administration of Branched Chain Amino Acids prevents bacterial translocation after liver resection in the cirrhotic rat

Takashi Higashiguchi, Akihiro Ito, Masato Kitagawa, Hiroki Taoka, Yoshifumi Kawarada

研究成果: Article査読

2 被引用数 (Scopus)

抄録

After major liver resection, bacterial infectious complications, including sepsis and endotoxemia, can be at least in part, attributed to translocation of enteric bacteria and endotoxin. We evaluated the effectiveness of the enterai and parenteral administration of branched-chain amino acids (BCAA) in preventing bacterial translocation after 70% liver resection in rats with thioacetamide-induced-cirrhosis. Bacterial translocation after hepatectomy was induced by a disturbance of protein metabolism in intestinal epithelial cells. However, the administration of BCAA, particularly via the enterai route, improved amino acid metabolism in the gut and stimulated the synthesis of nonsecreted protein and the proliferation of crypt cells, thereby preventing bacterial translocation after liver resection. Improvement in this cascade of metabolic reactions is believed to have been responsible for the improved outcome after extensive resection of the cirrhotic liver.

本文言語English
ページ(範囲)291-296
ページ数6
ジャーナルJournal of Hepato-Biliary-Pancreatic Surgery
3
3
DOI
出版ステータスPublished - 01-01-1996
外部発表はい

All Science Journal Classification (ASJC) codes

  • 外科
  • 肝臓学

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