Adoptive transfer of genetically engineered WT1-specific cytotoxic T lymphocytes does not induce renal injury

Hiroaki Asai; Hiroshi Fujiwara; Sohei Kitazawa; Naoto Kobayashi; Toshiki Ochi; Yukihiro Miyazaki; Fumihiro Ochi; Yoshiki Akatsuka; Sachiko Okamoto; Junichi Mineno; Kiyotaka Kuzushima; Hiroaki Ikeda; Hiroshi Shiku; Masaki Yasukawa

doi:10.1186/1756-8722-7-3

Adoptive transfer of genetically engineered WT1-specific cytotoxic T lymphocytes does not induce renal injury

Hiroaki Asai
, Hiroshi Fujiwara
, Sohei Kitazawa
, Naoto Kobayashi
, Toshiki Ochi
, Yukihiro Miyazaki
, Fumihiro Ochi
, Yoshiki Akatsuka
, Sachiko Okamoto
, Junichi Mineno
, Kiyotaka Kuzushima
, Hiroaki Ikeda
, Hiroshi Shiku
, Masaki Yasukawa

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

5 被引用数 (Scopus)

抄録

Because WT1 is expressed in leukemia cells, the development of cancer immunotherapy targeting WT1 has been an attractive translational research topic. However, concern of this therapy still remains, since WT1 is abundantly expressed in renal glomerular podocytes. In the present study, we clearly showed that WT1-specific cytotoxic T lymphocytes (CTLs) certainly exerted cytotoxicity against podocytes in vitro; however, they did not damage podocytes in vivo. This might be due to the anatomical localization of podocytes, being structurally separated from circulating CTLs in glomerular capillaries by an exceptionally thick basement membrane.

本文言語	英語
論文番号	3
ジャーナル	Journal of Hematology and Oncology
巻	7
号	1
DOI	https://doi.org/10.1186/1756-8722-7-3
出版ステータス	出版済み - 06-01-2014
外部発表	はい

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この成果は、次の持続可能な開発目標に貢献しています

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All Science Journal Classification (ASJC) codes

分子生物学
血液学
腫瘍学
癌研究

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10.1186/1756-8722-7-3

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Asai, H., Fujiwara, H., Kitazawa, S., Kobayashi, N., Ochi, T., Miyazaki, Y., Ochi, F., Akatsuka, Y., Okamoto, S., Mineno, J., Kuzushima, K., Ikeda, H., Shiku, H., & Yasukawa, M. (2014). Adoptive transfer of genetically engineered WT1-specific cytotoxic T lymphocytes does not induce renal injury. Journal of Hematology and Oncology, 7(1), 記事 3. https://doi.org/10.1186/1756-8722-7-3

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title = "Adoptive transfer of genetically engineered WT1-specific cytotoxic T lymphocytes does not induce renal injury",

abstract = "Because WT1 is expressed in leukemia cells, the development of cancer immunotherapy targeting WT1 has been an attractive translational research topic. However, concern of this therapy still remains, since WT1 is abundantly expressed in renal glomerular podocytes. In the present study, we clearly showed that WT1-specific cytotoxic T lymphocytes (CTLs) certainly exerted cytotoxicity against podocytes in vitro; however, they did not damage podocytes in vivo. This might be due to the anatomical localization of podocytes, being structurally separated from circulating CTLs in glomerular capillaries by an exceptionally thick basement membrane.",

author = "Hiroaki Asai and Hiroshi Fujiwara and Sohei Kitazawa and Naoto Kobayashi and Toshiki Ochi and Yukihiro Miyazaki and Fumihiro Ochi and Yoshiki Akatsuka and Sachiko Okamoto and Junichi Mineno and Kiyotaka Kuzushima and Hiroaki Ikeda and Hiroshi Shiku and Masaki Yasukawa",

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Asai, H, Fujiwara, H, Kitazawa, S, Kobayashi, N, Ochi, T, Miyazaki, Y, Ochi, F, Akatsuka, Y, Okamoto, S, Mineno, J, Kuzushima, K, Ikeda, H, Shiku, H & Yasukawa, M 2014, 'Adoptive transfer of genetically engineered WT1-specific cytotoxic T lymphocytes does not induce renal injury', Journal of Hematology and Oncology, vol. 7, no. 1, 3. https://doi.org/10.1186/1756-8722-7-3

TY - JOUR

T1 - Adoptive transfer of genetically engineered WT1-specific cytotoxic T lymphocytes does not induce renal injury

AU - Asai, Hiroaki

AU - Fujiwara, Hiroshi

AU - Kitazawa, Sohei

AU - Kobayashi, Naoto

AU - Ochi, Toshiki

AU - Miyazaki, Yukihiro

AU - Ochi, Fumihiro

AU - Akatsuka, Yoshiki

AU - Okamoto, Sachiko

AU - Mineno, Junichi

AU - Kuzushima, Kiyotaka

AU - Ikeda, Hiroaki

AU - Shiku, Hiroshi

AU - Yasukawa, Masaki

PY - 2014/1/6

Y1 - 2014/1/6

N2 - Because WT1 is expressed in leukemia cells, the development of cancer immunotherapy targeting WT1 has been an attractive translational research topic. However, concern of this therapy still remains, since WT1 is abundantly expressed in renal glomerular podocytes. In the present study, we clearly showed that WT1-specific cytotoxic T lymphocytes (CTLs) certainly exerted cytotoxicity against podocytes in vitro; however, they did not damage podocytes in vivo. This might be due to the anatomical localization of podocytes, being structurally separated from circulating CTLs in glomerular capillaries by an exceptionally thick basement membrane.

AB - Because WT1 is expressed in leukemia cells, the development of cancer immunotherapy targeting WT1 has been an attractive translational research topic. However, concern of this therapy still remains, since WT1 is abundantly expressed in renal glomerular podocytes. In the present study, we clearly showed that WT1-specific cytotoxic T lymphocytes (CTLs) certainly exerted cytotoxicity against podocytes in vitro; however, they did not damage podocytes in vivo. This might be due to the anatomical localization of podocytes, being structurally separated from circulating CTLs in glomerular capillaries by an exceptionally thick basement membrane.

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AN - SCOPUS:84891528521

SN - 1756-8722

VL - 7

JO - Journal of Hematology and Oncology

JF - Journal of Hematology and Oncology

IS - 1

M1 - 3

ER -

Adoptive transfer of genetically engineered WT1-specific cytotoxic T lymphocytes does not induce renal injury

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