Adrenaline enhances odorant contrast by modulating signal encoding in olfactory receptor cells

Fusao Kawai, Takashi Kurahashi, Akimichi Kaneko

研究成果: ジャーナルへの寄稿学術論文査読

101 被引用数 (Scopus)

抄録

Olfactory perception is influenced by hormones. Here we report that adrenaline can directly affect the signal encoding of olfactory receptor cells. Application of adrenaline suppressed action potentials near threshold and increased their frequency in response to strong stimuli, resulting in a narrower dynamic range. Under voltage-clamp conditions, adrenaline enhanced sodium current and reduced T-type calcium current. Because sodium current is the major component of spike generation and T-type calcium current lowers the threshold in olfactory receptor cells, the effects of adrenaline on these currents are consistent with the results obtained under current-clamp conditions. Both effects involved a common cytoplasmic pathway, cAMP- dependent phosphorylation. We suggest that adrenaline may enhance contrast in olfactory perception by this mechanism.

本文言語英語
ページ(範囲)133-138
ページ数6
ジャーナルNature Neuroscience
2
2
DOI
出版ステータス出版済み - 02-1999
外部発表はい

All Science Journal Classification (ASJC) codes

  • 神経科学一般

フィンガープリント

「Adrenaline enhances odorant contrast by modulating signal encoding in olfactory receptor cells」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル