Advancements in Cell-Based Therapies for HIV Cure

Yusuke Matsui, Yasuo Miura

研究成果: ジャーナルへの寄稿総説査読

1 被引用数 (Scopus)

抄録

The treatment of human immunodeficiency virus (HIV-1) has evolved since the establishment of combination antiretroviral therapy (ART) in the 1990s, providing HIV-infected individuals with approaches that suppress viral replication, prevent acquired immunodeficiency syndrome (AIDS) throughout their lifetime with continuous therapy, and halt HIV transmission. However, despite the success of these regimens, the global HIV epidemic persists, prompting a comprehensive exploration of potential strategies for an HIV cure. Here, we offer a consolidated overview of cell-based therapies for HIV-1, focusing on CAR-T cell approaches, gene editing, and immune modulation. Persistent challenges, including CAR-T cell susceptibility to HIV infection, stability, and viral reservoir control, underscore the need for continued research. This review synthesizes current knowledge, highlighting the potential of cellular therapies to address persistent challenges in the pursuit of an HIV cure.

本文言語英語
論文番号64
ジャーナルCells
13
1
DOI
出版ステータス出版済み - 01-2024

All Science Journal Classification (ASJC) codes

  • 生化学、遺伝学、分子生物学一般

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