TY - JOUR
T1 - Advances in defining signaling networks for the establishment of neuronal polarity
AU - Funahashi, Yasuhiro
AU - Watanabe, Takashi
AU - Kaibuchi, Kozo
N1 - Funding Information:
We thank Drs. Mutsuki Amano and Tetsuya Takano for helpful discussions. This work was supported by the following funding sources: AMED grant number JP19dm0207075 and JSPS KAKENHI grant numbers JP17H01380 and JP18K14849 .
PY - 2020/4
Y1 - 2020/4
N2 - Neurons are highly polarized cells that have structurally and functionally distinct processes called axons and dendrites. How neurons establish polarity is one of the fundamental questions of neuroscience. In the last decade, significant progress has been made in identifying and understanding the molecular mechanisms responsible for neuronal polarization, primarily through researches conducted on cultured neurons. Advances in phosphoproteomics technologies and molecular tools have enabled comprehensive signal analysis and visualization and manipulation of signaling molecules for analyzing neuronal polarity. Furthermore, advances in gene transfer techniques have revealed the role of extracellular and intracellular signaling molecules in neuronal polarization in vivo. This review discusses the latest insights and techniques for the elucidation of the molecular mechanisms that control neuronal polarity.
AB - Neurons are highly polarized cells that have structurally and functionally distinct processes called axons and dendrites. How neurons establish polarity is one of the fundamental questions of neuroscience. In the last decade, significant progress has been made in identifying and understanding the molecular mechanisms responsible for neuronal polarization, primarily through researches conducted on cultured neurons. Advances in phosphoproteomics technologies and molecular tools have enabled comprehensive signal analysis and visualization and manipulation of signaling molecules for analyzing neuronal polarity. Furthermore, advances in gene transfer techniques have revealed the role of extracellular and intracellular signaling molecules in neuronal polarization in vivo. This review discusses the latest insights and techniques for the elucidation of the molecular mechanisms that control neuronal polarity.
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U2 - 10.1016/j.ceb.2019.12.009
DO - 10.1016/j.ceb.2019.12.009
M3 - Review article
C2 - 32018218
AN - SCOPUS:85078677060
VL - 63
SP - 76
EP - 87
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
SN - 0955-0674
ER -