TY - CHAP
T1 - Afadin/AF-6 and canoe
T2 - Roles in cell adhesion and beyond
AU - Mandai, Kenji
AU - Rikitake, Yoshiyuki
AU - Shimono, Yohei
AU - Takai, Yoshimi
PY - 2013
Y1 - 2013
N2 - Afadin is an actin filament (F-actin) and Rap1 small G protein-binding protein encoded by the MLLT4/AF-6 gene. It is abundant at cadherin-based adherens junctions in epithelial cells, endothelial cells, and fibroblasts. It contains multiple domains and interacts with many proteins, including cell adhesion molecules and their associated molecules, and signaling molecules. Many lines of evidence show that afadin plays pleiotropic functions not only in the formation of cell junctions but also in cell polarization, migration, survival, proliferation, and differentiation. In addition, it is involved in oncogenesis and metastasis. Afadin is evolutionarily conserved from Caenorhabditis elegans to Homo sapiens. Canoe, the Drosophila melanogaster counterpart of afadin, is also localized at adherens junctions and regulates cell adhesion, cytoskeletal organization, planar cell polarity, cell differentiation, and migration. Moreover, canoe regulates asymmetric cell division of Drosophila neuroblasts. Thus, afadin/AF-6 and canoe are pivotal regulatory elements in many fundamental signaling cascades in cells.
AB - Afadin is an actin filament (F-actin) and Rap1 small G protein-binding protein encoded by the MLLT4/AF-6 gene. It is abundant at cadherin-based adherens junctions in epithelial cells, endothelial cells, and fibroblasts. It contains multiple domains and interacts with many proteins, including cell adhesion molecules and their associated molecules, and signaling molecules. Many lines of evidence show that afadin plays pleiotropic functions not only in the formation of cell junctions but also in cell polarization, migration, survival, proliferation, and differentiation. In addition, it is involved in oncogenesis and metastasis. Afadin is evolutionarily conserved from Caenorhabditis elegans to Homo sapiens. Canoe, the Drosophila melanogaster counterpart of afadin, is also localized at adherens junctions and regulates cell adhesion, cytoskeletal organization, planar cell polarity, cell differentiation, and migration. Moreover, canoe regulates asymmetric cell division of Drosophila neuroblasts. Thus, afadin/AF-6 and canoe are pivotal regulatory elements in many fundamental signaling cascades in cells.
UR - https://www.scopus.com/pages/publications/84875238639
UR - https://www.scopus.com/pages/publications/84875238639#tab=citedBy
U2 - 10.1016/B978-0-12-394311-8.00019-4
DO - 10.1016/B978-0-12-394311-8.00019-4
M3 - Chapter
C2 - 23481206
AN - SCOPUS:84875238639
SN - 9780123943118
T3 - Progress in Molecular Biology and Translational Science
SP - 433
EP - 454
BT - The Molecular Biology of Cadherins
PB - Elsevier B.V.
ER -