TY - JOUR
T1 - Albuminuria Predicts Short-Term Worsening Renal Function After Transcatheter Aortic Valve Replacement
AU - Tobe, Akihiro
AU - Tanaka, Akihito
AU - Tokuda, Yoshiyuki
AU - Shirai, Yoshinori
AU - Otsuka, Satoshi
AU - Yamamoto, Toshikuni
AU - Tokoro, Masayoshi
AU - Furusawa, Kenji
AU - Ishii, Hideki
AU - Usui, Akihiko
AU - Murohara, Toyoaki
N1 - Funding Information:
Hideki Ishii received lecture fees from Astellas Pharma Inc., AstraZeneca, Daiichi Sankyo Inc., MSD. Akihiko Usui received unrestricted research grants for department of cardiac surgery, Nagoya university graduate school of medicine from Terumo, Edwards Lifesciences Corporation, Senko Medical Instrument Manufacturing Co Ltd., Medtronic, Lifeline. Toyoaki Murohara received lecture fees from Bayer Pharmaceutical Co LTD, Daiichi Sankyo Co Ltd., Dainippon Sumitomo Pharma Co Ltd., Kowa Co Ltd., MSD, Mitsubishi Tanabe Pharma Corp, Nippon Boehringer Ingelheim Co Ltd., Novartis Pharma Kabushiki Kaisha, Pfizer Japan Inc., Sanofi-aventis, Takeda Pharmaceutical Co Ltd. Toyoaki Murohara received unrestricted research grants from Daiichi Sankyo Co Ltd., Dainippon Sumitomo Pharma Co Ltd., Kowa Co Ltd., MSD, Mitsubishi Tanabe Pharma Corp, Nippon Boehringer Ingelheim Co Ltd., Novartis Pharma Kabushiki Kaisha, Pfizer Japan Inc., Sanofi-aventis, Takeda Pharmaceutical Co Ltd., Astellas Pharma Inc., Otsuka Pharmaceutical Co Ltd., Teijin Pharma Ltd. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
Publisher Copyright:
© 2022 Elsevier Inc.
PY - 2022/9
Y1 - 2022/9
N2 - Albuminuria is a major risk factor of cardiovascular events, however, the impact of albuminuria on clinical outcomes of patients undergoing transcatheter aortic valve replacement (TAVR) has not been fully investigated. This retrospective study included 206 patients who underwent TAVR for severe aortic stenosis. Patients were divided into two groups according to the preoperative urinary albumin-to-creatinine ratio (ACR): high (ACR ≥ 30 mg/g) and low (ACR < 30 mg/g). The incidence of 1-month worsening renal function (WRF), defined as a decrease in estimated glomerular filtration rate (eGFR) ≥10% from baseline after TAVR, was investigated. Patients with high ACR had acute kidney injury (8.5% vs. 1.0%, p = 0.01) and 1-month WRF (29.2% vs. 12.0%, p = 0.002) more frequently than those with low ACR. High ACR was independently associated with 1-month WRF (odds ratio, 3.72; 95% confidence interval, 1.72–8.08; p < 0.001). Albuminuria can be a useful predictor of deterioration of renal function at various time points after TAVR.
AB - Albuminuria is a major risk factor of cardiovascular events, however, the impact of albuminuria on clinical outcomes of patients undergoing transcatheter aortic valve replacement (TAVR) has not been fully investigated. This retrospective study included 206 patients who underwent TAVR for severe aortic stenosis. Patients were divided into two groups according to the preoperative urinary albumin-to-creatinine ratio (ACR): high (ACR ≥ 30 mg/g) and low (ACR < 30 mg/g). The incidence of 1-month worsening renal function (WRF), defined as a decrease in estimated glomerular filtration rate (eGFR) ≥10% from baseline after TAVR, was investigated. Patients with high ACR had acute kidney injury (8.5% vs. 1.0%, p = 0.01) and 1-month WRF (29.2% vs. 12.0%, p = 0.002) more frequently than those with low ACR. High ACR was independently associated with 1-month WRF (odds ratio, 3.72; 95% confidence interval, 1.72–8.08; p < 0.001). Albuminuria can be a useful predictor of deterioration of renal function at various time points after TAVR.
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U2 - 10.1016/j.carrev.2022.03.014
DO - 10.1016/j.carrev.2022.03.014
M3 - Letter
C2 - 35361570
AN - SCOPUS:85135949763
VL - 42
SP - 178
EP - 181
JO - Cardiovascular Revascularization Medicine
JF - Cardiovascular Revascularization Medicine
SN - 1553-8389
ER -