Alcohol consumption and lung cancer mortality in Japanese men

Results from Japan collaborative cohort (JACC) study

Yoshikazu Nishino, Kenji Wakai, Takaaki Kondo, Nao Seki, Yoshinori Ito, Koji Suzuki, Kotaro Ozasa, Yoshiyuki Watanabe, Masahiko Ando, Yoshitaka Tsubono, Ichiro Tsuji, Akiko Tamakoshi, Mitsuru Mori, Yutaka Motohashi, Yosikazu Nakamura, Hiroyasu Iso, Haruo Mikami, Yutaka Inaba, Yoshiharu Hoshiyama, Hiroshi Suzuki & 20 others Hiroyuki Shimizu, Hideaki Toyoshima, Shinkan Tokudome, Shuji Hashimoto, Shogo Kikuchi, Akio Koizumi, Takashi Kawamura, Tsuneharu Miki, Chigusa Date, Kiyomi Sakata, Takayuki Nose, Norihiko Hayakawa, Takesumi Yoshimura, Akira Shibata, Naoyuki Okamoto, Hideo Shio, Yoshiyuki Ohno, Tomoyuki Kitagawa, Toshio Kuroki, Kazuo Tajima

研究成果: Article

24 引用 (Scopus)

抄録

Background: The relationship between alcohol consumption and increased risk of lung cancer is controversial. This study was set up to investigate the association between alcohol consumption and death from lung cancer in a large Japanese cohort. Methods: The subjects comprised 28,536 males, aged 40-79 years, living throughout Japan. During 268,464 person-years of follow-up, 377 lung cancer deaths were recorded. The hazard ratio (HR) of alcohol consumption for lung cancer mortality was calculated using the Cox proportional hazards model after adjustment for age, smoking and family history of lung cancer. Results: There was no association between increased mortality from lung cancer and alcohol consumption among current drinkers. Compared with subjects who had never drunk alcohol, the HRs (95% confidence interval [Cl]) of death from lung cancer for light (consuming <25.0 g ethanol per day), moderate (25.0-49.9 g per day) and heavy (≥50 g per day) drinkers were 0.81 (95% Cl=0.61-1.07), 0.82 (0.61-1.11) and 0.97 (0.66-1.43), respectively. Further adjustment for fruit and vegetable intake did not change the results, and there was no change in HR materially after excluding those patients who died during the first 5 years of follow-up. Conclusions: These findings indicate that alcohol consumption was not associated with increased lung cancer mortality in this population of Japanese men.

元の言語English
ページ(範囲)49-56
ページ数8
ジャーナルJournal of epidemiology
16
発行部数2
DOI
出版物ステータスPublished - 14-03-2006

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Alcohol Drinking
Lung Neoplasms
Japan
Cohort Studies
Mortality
Proportional Hazards Models
Vegetables
Fruit
Ethanol
Smoking
Alcohols
Confidence Intervals
Light
Population

All Science Journal Classification (ASJC) codes

  • Epidemiology

これを引用

Nishino, Yoshikazu ; Wakai, Kenji ; Kondo, Takaaki ; Seki, Nao ; Ito, Yoshinori ; Suzuki, Koji ; Ozasa, Kotaro ; Watanabe, Yoshiyuki ; Ando, Masahiko ; Tsubono, Yoshitaka ; Tsuji, Ichiro ; Tamakoshi, Akiko ; Mori, Mitsuru ; Motohashi, Yutaka ; Nakamura, Yosikazu ; Iso, Hiroyasu ; Mikami, Haruo ; Inaba, Yutaka ; Hoshiyama, Yoshiharu ; Suzuki, Hiroshi ; Shimizu, Hiroyuki ; Toyoshima, Hideaki ; Tokudome, Shinkan ; Hashimoto, Shuji ; Kikuchi, Shogo ; Koizumi, Akio ; Kawamura, Takashi ; Miki, Tsuneharu ; Date, Chigusa ; Sakata, Kiyomi ; Nose, Takayuki ; Hayakawa, Norihiko ; Yoshimura, Takesumi ; Shibata, Akira ; Okamoto, Naoyuki ; Shio, Hideo ; Ohno, Yoshiyuki ; Kitagawa, Tomoyuki ; Kuroki, Toshio ; Tajima, Kazuo. / Alcohol consumption and lung cancer mortality in Japanese men : Results from Japan collaborative cohort (JACC) study. :: Journal of epidemiology. 2006 ; 巻 16, 番号 2. pp. 49-56.
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title = "Alcohol consumption and lung cancer mortality in Japanese men: Results from Japan collaborative cohort (JACC) study",
abstract = "Background: The relationship between alcohol consumption and increased risk of lung cancer is controversial. This study was set up to investigate the association between alcohol consumption and death from lung cancer in a large Japanese cohort. Methods: The subjects comprised 28,536 males, aged 40-79 years, living throughout Japan. During 268,464 person-years of follow-up, 377 lung cancer deaths were recorded. The hazard ratio (HR) of alcohol consumption for lung cancer mortality was calculated using the Cox proportional hazards model after adjustment for age, smoking and family history of lung cancer. Results: There was no association between increased mortality from lung cancer and alcohol consumption among current drinkers. Compared with subjects who had never drunk alcohol, the HRs (95{\%} confidence interval [Cl]) of death from lung cancer for light (consuming <25.0 g ethanol per day), moderate (25.0-49.9 g per day) and heavy (≥50 g per day) drinkers were 0.81 (95{\%} Cl=0.61-1.07), 0.82 (0.61-1.11) and 0.97 (0.66-1.43), respectively. Further adjustment for fruit and vegetable intake did not change the results, and there was no change in HR materially after excluding those patients who died during the first 5 years of follow-up. Conclusions: These findings indicate that alcohol consumption was not associated with increased lung cancer mortality in this population of Japanese men.",
author = "Yoshikazu Nishino and Kenji Wakai and Takaaki Kondo and Nao Seki and Yoshinori Ito and Koji Suzuki and Kotaro Ozasa and Yoshiyuki Watanabe and Masahiko Ando and Yoshitaka Tsubono and Ichiro Tsuji and Akiko Tamakoshi and Mitsuru Mori and Yutaka Motohashi and Yosikazu Nakamura and Hiroyasu Iso and Haruo Mikami and Yutaka Inaba and Yoshiharu Hoshiyama and Hiroshi Suzuki and Hiroyuki Shimizu and Hideaki Toyoshima and Shinkan Tokudome and Shuji Hashimoto and Shogo Kikuchi and Akio Koizumi and Takashi Kawamura and Tsuneharu Miki and Chigusa Date and Kiyomi Sakata and Takayuki Nose and Norihiko Hayakawa and Takesumi Yoshimura and Akira Shibata and Naoyuki Okamoto and Hideo Shio and Yoshiyuki Ohno and Tomoyuki Kitagawa and Toshio Kuroki and Kazuo Tajima",
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pages = "49--56",
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Nishino, Y, Wakai, K, Kondo, T, Seki, N, Ito, Y, Suzuki, K, Ozasa, K, Watanabe, Y, Ando, M, Tsubono, Y, Tsuji, I, Tamakoshi, A, Mori, M, Motohashi, Y, Nakamura, Y, Iso, H, Mikami, H, Inaba, Y, Hoshiyama, Y, Suzuki, H, Shimizu, H, Toyoshima, H, Tokudome, S, Hashimoto, S, Kikuchi, S, Koizumi, A, Kawamura, T, Miki, T, Date, C, Sakata, K, Nose, T, Hayakawa, N, Yoshimura, T, Shibata, A, Okamoto, N, Shio, H, Ohno, Y, Kitagawa, T, Kuroki, T & Tajima, K 2006, 'Alcohol consumption and lung cancer mortality in Japanese men: Results from Japan collaborative cohort (JACC) study', Journal of epidemiology, 巻. 16, 番号 2, pp. 49-56. https://doi.org/10.2188/jea.16.49

Alcohol consumption and lung cancer mortality in Japanese men : Results from Japan collaborative cohort (JACC) study. / Nishino, Yoshikazu; Wakai, Kenji; Kondo, Takaaki; Seki, Nao; Ito, Yoshinori; Suzuki, Koji; Ozasa, Kotaro; Watanabe, Yoshiyuki; Ando, Masahiko; Tsubono, Yoshitaka; Tsuji, Ichiro; Tamakoshi, Akiko; Mori, Mitsuru; Motohashi, Yutaka; Nakamura, Yosikazu; Iso, Hiroyasu; Mikami, Haruo; Inaba, Yutaka; Hoshiyama, Yoshiharu; Suzuki, Hiroshi; Shimizu, Hiroyuki; Toyoshima, Hideaki; Tokudome, Shinkan; Hashimoto, Shuji; Kikuchi, Shogo; Koizumi, Akio; Kawamura, Takashi; Miki, Tsuneharu; Date, Chigusa; Sakata, Kiyomi; Nose, Takayuki; Hayakawa, Norihiko; Yoshimura, Takesumi; Shibata, Akira; Okamoto, Naoyuki; Shio, Hideo; Ohno, Yoshiyuki; Kitagawa, Tomoyuki; Kuroki, Toshio; Tajima, Kazuo.

:: Journal of epidemiology, 巻 16, 番号 2, 14.03.2006, p. 49-56.

研究成果: Article

TY - JOUR

T1 - Alcohol consumption and lung cancer mortality in Japanese men

T2 - Results from Japan collaborative cohort (JACC) study

AU - Nishino, Yoshikazu

AU - Wakai, Kenji

AU - Kondo, Takaaki

AU - Seki, Nao

AU - Ito, Yoshinori

AU - Suzuki, Koji

AU - Ozasa, Kotaro

AU - Watanabe, Yoshiyuki

AU - Ando, Masahiko

AU - Tsubono, Yoshitaka

AU - Tsuji, Ichiro

AU - Tamakoshi, Akiko

AU - Mori, Mitsuru

AU - Motohashi, Yutaka

AU - Nakamura, Yosikazu

AU - Iso, Hiroyasu

AU - Mikami, Haruo

AU - Inaba, Yutaka

AU - Hoshiyama, Yoshiharu

AU - Suzuki, Hiroshi

AU - Shimizu, Hiroyuki

AU - Toyoshima, Hideaki

AU - Tokudome, Shinkan

AU - Hashimoto, Shuji

AU - Kikuchi, Shogo

AU - Koizumi, Akio

AU - Kawamura, Takashi

AU - Miki, Tsuneharu

AU - Date, Chigusa

AU - Sakata, Kiyomi

AU - Nose, Takayuki

AU - Hayakawa, Norihiko

AU - Yoshimura, Takesumi

AU - Shibata, Akira

AU - Okamoto, Naoyuki

AU - Shio, Hideo

AU - Ohno, Yoshiyuki

AU - Kitagawa, Tomoyuki

AU - Kuroki, Toshio

AU - Tajima, Kazuo

PY - 2006/3/14

Y1 - 2006/3/14

N2 - Background: The relationship between alcohol consumption and increased risk of lung cancer is controversial. This study was set up to investigate the association between alcohol consumption and death from lung cancer in a large Japanese cohort. Methods: The subjects comprised 28,536 males, aged 40-79 years, living throughout Japan. During 268,464 person-years of follow-up, 377 lung cancer deaths were recorded. The hazard ratio (HR) of alcohol consumption for lung cancer mortality was calculated using the Cox proportional hazards model after adjustment for age, smoking and family history of lung cancer. Results: There was no association between increased mortality from lung cancer and alcohol consumption among current drinkers. Compared with subjects who had never drunk alcohol, the HRs (95% confidence interval [Cl]) of death from lung cancer for light (consuming <25.0 g ethanol per day), moderate (25.0-49.9 g per day) and heavy (≥50 g per day) drinkers were 0.81 (95% Cl=0.61-1.07), 0.82 (0.61-1.11) and 0.97 (0.66-1.43), respectively. Further adjustment for fruit and vegetable intake did not change the results, and there was no change in HR materially after excluding those patients who died during the first 5 years of follow-up. Conclusions: These findings indicate that alcohol consumption was not associated with increased lung cancer mortality in this population of Japanese men.

AB - Background: The relationship between alcohol consumption and increased risk of lung cancer is controversial. This study was set up to investigate the association between alcohol consumption and death from lung cancer in a large Japanese cohort. Methods: The subjects comprised 28,536 males, aged 40-79 years, living throughout Japan. During 268,464 person-years of follow-up, 377 lung cancer deaths were recorded. The hazard ratio (HR) of alcohol consumption for lung cancer mortality was calculated using the Cox proportional hazards model after adjustment for age, smoking and family history of lung cancer. Results: There was no association between increased mortality from lung cancer and alcohol consumption among current drinkers. Compared with subjects who had never drunk alcohol, the HRs (95% confidence interval [Cl]) of death from lung cancer for light (consuming <25.0 g ethanol per day), moderate (25.0-49.9 g per day) and heavy (≥50 g per day) drinkers were 0.81 (95% Cl=0.61-1.07), 0.82 (0.61-1.11) and 0.97 (0.66-1.43), respectively. Further adjustment for fruit and vegetable intake did not change the results, and there was no change in HR materially after excluding those patients who died during the first 5 years of follow-up. Conclusions: These findings indicate that alcohol consumption was not associated with increased lung cancer mortality in this population of Japanese men.

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U2 - 10.2188/jea.16.49

DO - 10.2188/jea.16.49

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JO - Journal of Epidemiology

JF - Journal of Epidemiology

SN - 0917-5040

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