Alcohol reduces insulin-hypertension relationship in a general population: The Hisayama study

Hisatomi Arima, Yutaka Kiyohara, Isao Kato, Yumihiro Tanizaki, Michiaki Kubo, Hiromitsu Iwamoto, Keiichi Tanaka, Isao Abe, Masatoshi Fujishima

研究成果: Article査読

18 被引用数 (Scopus)

抄録

Insulin resistance may be a factor in the etiology of hypertension, and habitual alcohol intake may modify this relationship. We prospectively examined this hypothesis in 1,133 nonhypertensive, nondiabetic Japanese subjects, aged 40-79 years. Alcohol drinkers were more frequent among men than women at baseline (57.7 vs. 8.2%). The age-adjusted incidence of hypertension significantly increased with the elevating baseline insulin levels in women (P = .003 for trend), but not in men. The age- and sex-adjusted insulin levels and insulin resistance index decreased with elevating alcohol intake, while fasting glucose levels remained unchanged, suggesting that alcohol improves insulin sensitivity. Among nondrinkers, the age-adjusted incidence of hypertension significantly increased with elevating insulin tertiles in both sexes (P = .048 and .002 for trend in men and women, respectively), but not among drinkers. Our findings suggest a close association between insulin resistance and the incidence of hypertension in Japanese. However, alcohol modified and reduced this relationship.

本文言語English
ページ(範囲)863-869
ページ数7
ジャーナルJournal of Clinical Epidemiology
55
9
DOI
出版ステータスPublished - 01-09-2002

All Science Journal Classification (ASJC) codes

  • 疫学

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