TY - JOUR
T1 - Alcohol reduces insulin-hypertension relationship in a general population
T2 - The Hisayama study
AU - Arima, Hisatomi
AU - Kiyohara, Yutaka
AU - Kato, Isao
AU - Tanizaki, Yumihiro
AU - Kubo, Michiaki
AU - Iwamoto, Hiromitsu
AU - Tanaka, Keiichi
AU - Abe, Isao
AU - Fujishima, Masatoshi
N1 - Funding Information:
Preparation of this article was supported in part by a Grant-in-Aid for Scientific Research (C) from the Ministry of Education, Science, Sports and Culture of Japan (No.#10670354). The authors thank the residents of Hisayama for their participation in the survey and the staff of the Division of Health and Welfare of Hisayama for their cooperation in this study. They are also grateful to Emeritus Professor Shibanosuke Katsuki; Yasuo Hirota, MD; Moriyuki Takeshita, MD; Kazuo Ueda, MD; Yutaka Hasuo, MD, Kyushu University, Fukuoka, Japan; and Teruo Omae, Emeritus President of the National Cardiovascular Disease Center, Osaka, Japan, for their devotion to the Hisayama study.
PY - 2002/9/1
Y1 - 2002/9/1
N2 - Insulin resistance may be a factor in the etiology of hypertension, and habitual alcohol intake may modify this relationship. We prospectively examined this hypothesis in 1,133 nonhypertensive, nondiabetic Japanese subjects, aged 40-79 years. Alcohol drinkers were more frequent among men than women at baseline (57.7 vs. 8.2%). The age-adjusted incidence of hypertension significantly increased with the elevating baseline insulin levels in women (P = .003 for trend), but not in men. The age- and sex-adjusted insulin levels and insulin resistance index decreased with elevating alcohol intake, while fasting glucose levels remained unchanged, suggesting that alcohol improves insulin sensitivity. Among nondrinkers, the age-adjusted incidence of hypertension significantly increased with elevating insulin tertiles in both sexes (P = .048 and .002 for trend in men and women, respectively), but not among drinkers. Our findings suggest a close association between insulin resistance and the incidence of hypertension in Japanese. However, alcohol modified and reduced this relationship.
AB - Insulin resistance may be a factor in the etiology of hypertension, and habitual alcohol intake may modify this relationship. We prospectively examined this hypothesis in 1,133 nonhypertensive, nondiabetic Japanese subjects, aged 40-79 years. Alcohol drinkers were more frequent among men than women at baseline (57.7 vs. 8.2%). The age-adjusted incidence of hypertension significantly increased with the elevating baseline insulin levels in women (P = .003 for trend), but not in men. The age- and sex-adjusted insulin levels and insulin resistance index decreased with elevating alcohol intake, while fasting glucose levels remained unchanged, suggesting that alcohol improves insulin sensitivity. Among nondrinkers, the age-adjusted incidence of hypertension significantly increased with elevating insulin tertiles in both sexes (P = .048 and .002 for trend in men and women, respectively), but not among drinkers. Our findings suggest a close association between insulin resistance and the incidence of hypertension in Japanese. However, alcohol modified and reduced this relationship.
KW - Alcohol
KW - Hypertension
KW - Incidence
KW - Insulin
KW - Insulin resistance
KW - Prospective studies
UR - https://www.scopus.com/pages/publications/0036709996
UR - https://www.scopus.com/pages/publications/0036709996#tab=citedBy
U2 - 10.1016/S0895-4356(02)00441-9
DO - 10.1016/S0895-4356(02)00441-9
M3 - Article
C2 - 12393073
AN - SCOPUS:0036709996
SN - 0895-4356
VL - 55
SP - 863
EP - 869
JO - Journal of Clinical Epidemiology
JF - Journal of Clinical Epidemiology
IS - 9
ER -