Allogeneic Bone Marrow Transplantation from Unrelated Human T-Cell Leukemia Virus-I-negative Donors for Adult T-Cell Leukemia/Lymphoma: Retrospective Analysis of Data from the Japan Marrow Donor Program

Koji Kato, Yoshinobu Kanda, Tetsuya Eto, Tsuyoshi Muta, Hisashi Gondo, Shuichi Taniguchi, Tsunefumi Shibuya, Atae Utsunomiya, Takakazu Kawase, Shunichi Kato, Yasuo Morishima, Yoshihisa Kodera, Mine Harada

研究成果: Article査読

46 被引用数 (Scopus)

抄録

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) from an HLA-matched related donor has been suggested to improve the poor prognosis of adult T-cell leukemia/lymphoma (ATLL). However, the infusion of HTLV-I-infected cells from HTLV-I-positive related donors could lead to the development of donor-derived ATLL under immunosuppressive conditions. Although most ATLL patients lack a suitable HLA-matched related donor and require an HTLV-I-negative unrelated donor, little information is currently available regarding the outcome of unrelated bone marrow transplantation (UBMT) for ATLL. To evaluate the role of UBMT in treating ATLL, we retrospectively analyzed data from 33 patients with ATLL treated by UBMT through the Japan Marrow Donor Program (JMDP). Overall survival (OS), progression-free survival, and cumulative incidence of disease progression and progression-free mortality at 1 year after UBMT were 49.5%, 49.2%, 18.6%, and 32.3%, respectively. Multivariate analysis identified recipient age as an independent prognostic factor for OS (P = .044). Patients age ≥50 years who showed nonremission at transplantation tended to have higher rates of treatment-related mortality. Our observations suggest that UBMT could represent a feasible treatment option for ATLL patients and warrant further investigation based on these risk factors.

本文言語English
ページ(範囲)90-99
ページ数10
ジャーナルBiology of Blood and Marrow Transplantation
13
1
DOI
出版ステータスPublished - 01-2007
外部発表はい

All Science Journal Classification (ASJC) codes

  • 血液学
  • 移植

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