TY - JOUR
T1 - Allotype-linked immune response genes
T2 - Roles in network control of the immune system
AU - Nakashima, I.
AU - Isobe, K.
AU - Yoshida, T.
AU - Iwamoto, T.
AU - Nagase, F.
AU - Zhang, Y. H.
AU - Pu, M.
AU - Lwin, T.
PY - 1991
Y1 - 1991
N2 - Studies on allotype-linked immune response genes and related genes are overviewed with particular attention to our current results in unique models. Significance of actions of various immune response genes in relation to allelic polymorphism of molecules in the immune system is discussed. The molecules involve immunoglobulins, T cell receptors, major histocompatibility complex and a number of cell interaction molecules, many of which belong to the immunoglobulin superfamily. Differential roles of V-linked and C-linked immune response genes for network control of the immune system, preparing the V structure repertoire, controlling antigen presentation and modulating the effector mechanism, are suggested.
AB - Studies on allotype-linked immune response genes and related genes are overviewed with particular attention to our current results in unique models. Significance of actions of various immune response genes in relation to allelic polymorphism of molecules in the immune system is discussed. The molecules involve immunoglobulins, T cell receptors, major histocompatibility complex and a number of cell interaction molecules, many of which belong to the immunoglobulin superfamily. Differential roles of V-linked and C-linked immune response genes for network control of the immune system, preparing the V structure repertoire, controlling antigen presentation and modulating the effector mechanism, are suggested.
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M3 - Review article
C2 - 1799457
AN - SCOPUS:0026351167
SN - 0254-9670
VL - 8
SP - 121
EP - 139
JO - Experimental and Clinical Immunogenetics
JF - Experimental and Clinical Immunogenetics
IS - 3
ER -