Alteration of colonic mucin after ureterosigmoidostomy

Chikao Shimamoto, Ichiro Hirata, Yujiro Takao, Hiroya Takiuchi, Hiroshi Morikawa, Yoshihito Nakagawa, Ken Ichi Katsu

研究成果: Article

11 引用 (Scopus)

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PURPOSE: Patients undergoing urinary diversion by ureterosigmoidostomy after complete cystectomy for malignant bladder tumors show a high incidence of neoplasia at and near the site of anastomosis. We examined a risk factor for tumor occurrence in the area of anastomosis, alterations of mucus glycoproteins in the surrounding colonic mucosa. METHODS: Colonoscopy was performed in 37 patients who had undergone ureterosigmoidostomy. Biopsy specimens were obtained near the ureteral anastomosis and were stained with hematoxylin and eosin, high iron-diamine alcian blue (pH 2.5), and a fluorescent lectin conjugate (peanut agglutinin). RESULTS: At the anastomotic site colonoscopy showed protruding lesions in 26 of 37 patients (71 percent), all histologically representing inflammatory granulomas. The mucosa around the anastomosis was normal in endoscopic appearance; however, histologically, slight inflammatory cell infiltration, edema, and increased numbers of Paneth cells were observed. Alcian blue staining revealed an increase in mucosal sialomucin postoperatively compared with preoperatively. The proportion of peanut agglutinin-binding mucin, not observed in normal mucosa but seen in malignant or premalignant tissue, was increased. CONCLUSION: As postoperative interval increases, changes in properties of the 'background' mucosa become greater, which suggests an association with colonic carcinogenesis.

元の言語English
ページ(範囲)526-531
ページ数6
ジャーナルDiseases of the Colon and Rectum
43
発行部数4
DOI
出版物ステータスPublished - 04-2000
外部発表Yes

All Science Journal Classification (ASJC) codes

  • Gastroenterology

フィンガープリント Alteration of colonic mucin after ureterosigmoidostomy' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

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    Shimamoto, C., Hirata, I., Takao, Y., Takiuchi, H., Morikawa, H., Nakagawa, Y., & Katsu, K. I. (2000). Alteration of colonic mucin after ureterosigmoidostomy. Diseases of the Colon and Rectum, 43(4), 526-531. https://doi.org/10.1007/BF02237199