Alteration of specific cytokine expression patterns in patients with breast cancer

Kosuke Kawaguchi, Masashi Sakurai, Yasuko Yamamoto, Eiji Suzuki, Moe Tsuda, Tatsuki R. Kataoka, Masahiro Hirata, Mariko Nishie, Takashi Nojiri, Motofumi Kumazoe, Kuniaki Saito, Masakazu Toi

研究成果: Article査読

5 被引用数 (Scopus)

抄録

Systemic inflammation has been associated with aggressive tumor growth, invasion, and metastasis. Here we performed a comprehensive analysis of 26 kinds of inflammatory cytokine expression patterns among 185 patients with breast cancer and 54 healthy volunteers followed by chemometric analysis. We identified the specific cytokine expression patterns of breast cancer patients compared to healthy volunteers with (1) VEGF, IL-9, GM-CSF, IL-13, IL-4, and IFNγ, (2) IL-8, IL-10, IL-12, IL-5, IL-7, IL-1α, GCSF, IL-1β, and TNFα and (3) IL-2, Eotaxin, MIP1β, MIP1α, IL-17, and bFGF. Among the patients with breast cancer, we identified the specific cytokine signature of metastatic patients compared to non-metastatic patients. We also established a mathematical model for distinguishing patients with breast cancer from healthy volunteers and metastatic patients from non-metastatic patients. This cytokine network analysis could provide new insights into early intervention and effective therapeutic strategy for patients with breast cancer.

本文言語English
論文番号2924
ジャーナルScientific reports
9
1
DOI
出版ステータスPublished - 01-12-2019

All Science Journal Classification (ASJC) codes

  • General

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