Alterations in Cognition-Related Cerebello-Cerebral Networks in Multiple System Atrophy

Kazuya Kawabata, Kazuhiro Hara, Hirohisa Watanabe, Epifanio Bagarinao, Aya Ogura, Michihito Masuda, Takamasa Yokoi, Toshiyasu Kato, Reiko Ohdake, Mizuki Ito, Masahisa Katsuno, Gen Sobue

研究成果: ジャーナルへの寄稿学術論文査読

16 被引用数 (Scopus)


We aimed to elucidate the effect of cerebellar degeneration in relation to cognition in multiple system atrophy (MSA). Thirty-two patients diagnosed with probable MSA and 32 age- and gender-matched healthy controls (HCs) were enrolled. We conducted voxel-based morphometry (VBM) for anatomical images and independent component analysis (ICA), dual-regression analysis, and seed-based analysis for functional images with voxel-wise gray matter correction. In the MSA group, a widespread cerebellar volume loss was observed. ICA and dual-regression analysis showed lower functional connectivity (FC) in the left executive control and salience networks in regions located in the cerebellum. Seed-based analysis using the identified cerebellar regions as seeds showed extensive disruptions in cerebello-cerebral networks. Global cognitive scores correlated with the FC values between the right lobules VI/crus I and the medial prefrontal/anterior cingulate cortices and between the same region and the amygdala/parahippocampal gyrus. Our study indicates that cerebellar degeneration in MSA causes segregation of cerebellar-cerebral networks. Furthermore, the cognitive deficits in MSA may be driven by decreased cerebello-prefrontal and cerebello-amygdaloid functional connections.

出版ステータス出版済み - 15-08-2019

All Science Journal Classification (ASJC) codes

  • 神経学
  • 臨床神経学


「Alterations in Cognition-Related Cerebello-Cerebral Networks in Multiple System Atrophy」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。