Alterations of GABAergic and dopaminergic systems in mutant mice with disruption of exons 2 and 3 of the Disc1 gene

Tsuyoshi Nakai, Taku Nagai, Rui Wang, Shinnosuke Yamada, Keisuke Kuroda, Kozo Kaibuchi, Kiyofumi Yamada

研究成果: ジャーナルへの寄稿学術論文査読

36 被引用数 (Scopus)

抄録

Disrupted-in-schizophrenia-1 (DISC1) has been widely associated with several psychiatric disorders, including schizophrenia, mood disorders and autism. We previously reported that a deficiency of DISC1 may induce low anxiety and/or high impulsivity in mice with disruption of exons 2 and 3 of the Disc1 gene (Disc1Δ2-3/Δ2- 3). It remains unclear, however, if deficiency of DISC1 leads to specific alterations in distinct neuronal systems. In the present study, to understand the role of DISC1 in γ-aminobutyric acid (GABA) interneurons and mesocorticolimbic dopaminergic (DAergic) neurons, we investigated the number of parvalbumin (PV)-positive interneurons, methamphetamine (METH)-induced DA release and the expression levels of GABAA, DA transporter (DAT) and DA receptors in wild-type (Disc1+/+) and Disc1 Δ2-3/Δ2-3 mice. Female Disc1Δ2-3/Δ2 -3 mice showed a significant reduction of PV-positive interneurons in the hippocampus, while no apparent changes were observed in mRNA expression levels of GABAA receptor subunits. METH-induced DA release was significantly potentiated in the nucleus accumbens (NAc) of female Disc1Δ2-3/Δ2- 3 mice, although there were no significant differences in the expression levels of DAT. Furthermore, the expression levels of DA receptor mRNA were upregulated in the NAc of female Disc1Δ2- 3/Δ2-3 mice. Male Disc1 Δ2-3/Δ2-3 mice showed no apparent differences in all experiments. DISC1 may play a critical role in gender-specific developmental alteration in GABAergic inhibitory interneurons and DAergic neurons.

本文言語英語
ページ(範囲)74-83
ページ数10
ジャーナルNeurochemistry International
74
DOI
出版ステータス出版済み - 07-2014
外部発表はい

All Science Journal Classification (ASJC) codes

  • 細胞および分子神経科学
  • 細胞生物学

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