TY - JOUR
T1 - Altered distribution of resting periods of daily locomotor activity in patients with delayed sleep phase disorder
AU - Hirose, Marina
AU - Nakamura, Toru
AU - Watanabe, Akiko
AU - Esaki, Yuichi
AU - Koike, Shigefumi
AU - Yamamoto, Yoshiharu
AU - Iwata, Nakao
AU - Kitajima, Tsuyoshi
N1 - Publisher Copyright:
Copyright © 2022 Hirose, Nakamura, Watanabe, Esaki, Koike, Yamamoto, Iwata and Kitajima.
PY - 2022/10/13
Y1 - 2022/10/13
N2 - Delayed sleep phase disorder (DSPD) and mood disorders have a close relationship. However, the shared mechanisms by DSPD and mood disorders have not been well-elucidated. We previously found that micro-fluctuations in human behaviors are organized by robust statistical laws (behavioral organization), where the cumulative distributions of resting and active period durations take a power-law distribution form and a stretched exponential functional form, respectively. Further, we found that the scaling exponents of resting period distributions significantly decreased in major depressive disorder (MDD). In this study, we hypothesized that DSPD had similar characteristics of the altered behavioral organization to that of MDD. Locomotor activity data were acquired for more than 1 week from 17 patients with DSPD and 17 age- and gender-matched healthy participants using actigraphy. We analyzed the cumulative distributions of resting and active period durations in locomotor activity data and subsequently derived fitting parameters of those distributions. Similar to patients with MDD, we found that resting period distributions took a power-law form over the range of 2–100 min, with significantly lower values of scaling exponents γ in patients with DSPD compared with healthy participants. The shared alteration in γ suggests the existence of similar pathophysiology between DSPD and MDD.
AB - Delayed sleep phase disorder (DSPD) and mood disorders have a close relationship. However, the shared mechanisms by DSPD and mood disorders have not been well-elucidated. We previously found that micro-fluctuations in human behaviors are organized by robust statistical laws (behavioral organization), where the cumulative distributions of resting and active period durations take a power-law distribution form and a stretched exponential functional form, respectively. Further, we found that the scaling exponents of resting period distributions significantly decreased in major depressive disorder (MDD). In this study, we hypothesized that DSPD had similar characteristics of the altered behavioral organization to that of MDD. Locomotor activity data were acquired for more than 1 week from 17 patients with DSPD and 17 age- and gender-matched healthy participants using actigraphy. We analyzed the cumulative distributions of resting and active period durations in locomotor activity data and subsequently derived fitting parameters of those distributions. Similar to patients with MDD, we found that resting period distributions took a power-law form over the range of 2–100 min, with significantly lower values of scaling exponents γ in patients with DSPD compared with healthy participants. The shared alteration in γ suggests the existence of similar pathophysiology between DSPD and MDD.
UR - http://www.scopus.com/inward/record.url?scp=85140759340&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85140759340&partnerID=8YFLogxK
U2 - 10.3389/fpsyt.2022.933690
DO - 10.3389/fpsyt.2022.933690
M3 - Article
AN - SCOPUS:85140759340
SN - 1664-0640
VL - 13
JO - Frontiers in Psychiatry
JF - Frontiers in Psychiatry
M1 - 933690
ER -