Altered genomic imprinting in the IGF2 and H19 genes in human lung cancer

M. Kondo, T. Takahashi

研究成果: Review article査読

11 被引用数 (Scopus)

抄録

Genomic imprinting is defined as a gamete-specific modification causing differential expression of the two alleles of a gene in somatic cells. While insulin-like growth factor 2 (IGF2) and H19 both at 11p15 are imprinted in normal lung, we observed frequent loss of imprinting (LOI) of the IGF2 and H19 genes in the lung cancer. While genomic imprinting is thought to play an important role in embryonal development and possibly in the development of certain embryonal tumors such as Wilms' tumor, these results suggest that altered imprinting may also play a role in the oncogenesis of this common cancer of adults, lung cancer.

本文言語English
ページ(範囲)492-496
ページ数5
ジャーナルNippon rinsho. Japanese journal of clinical medicine
54
2
出版ステータスPublished - 02-1996
外部発表はい

All Science Journal Classification (ASJC) codes

  • 医学(全般)

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