Altered genomic imprinting in the IGF2 and H19 genes in human lung cancer

Masashi Kondo, T. Takahashi

研究成果: Review article

11 引用 (Scopus)

抄録

Genomic imprinting is defined as a gamete-specific modification causing differential expression of the two alleles of a gene in somatic cells. While insulin-like growth factor 2 (IGF2) and H19 both at 11p15 are imprinted in normal lung, we observed frequent loss of imprinting (LOI) of the IGF2 and H19 genes in the lung cancer. While genomic imprinting is thought to play an important role in embryonal development and possibly in the development of certain embryonal tumors such as Wilms' tumor, these results suggest that altered imprinting may also play a role in the oncogenesis of this common cancer of adults, lung cancer.

元の言語English
ページ(範囲)492-496
ページ数5
ジャーナルNippon rinsho. Japanese journal of clinical medicine
54
発行部数2
出版物ステータスPublished - 01-01-1996

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Genomic Imprinting
Somatomedins
Lung Neoplasms
Genes
Wilms Tumor
Germ Cells
Carcinogenesis
Alleles
Lung
Neoplasms

All Science Journal Classification (ASJC) codes

  • Medicine(all)

これを引用

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Altered genomic imprinting in the IGF2 and H19 genes in human lung cancer. / Kondo, Masashi; Takahashi, T.

:: Nippon rinsho. Japanese journal of clinical medicine, 巻 54, 番号 2, 01.01.1996, p. 492-496.

研究成果: Review article

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