Alternate repetition of short fore- and backfiltrations reduces convective albumin loss

Toru Shinzato, Masamiki Miwa, Shigeru Nakai, Ichiro Takai, Yoshihiro Matsumoto, Hiroyuki Morita, Toshio Miyata, Kenji Maeda

研究成果: Article査読

26 被引用数 (Scopus)

抄録

An effective therapeutic means to remove relatively large polypeptide uremic toxins stems to be a hemofiltration (HF) or hemodiafiltration (HDF) employing a larger-pore membrane, that is, a protein-permeable membrane. With either method, however, a significant amount of albumin will be lost into the ultrafiltrate or dialysate. Now, repetition of alternate short fore- and backfiltrations may prevent the development of the ultrafiltration-induced higher albumin concentration on the membrane surface (protein concentration polarization), where a single forefiltration time is shorter than the time needed for completion of protein concentration polarization. Since the albumin concentration on the protein-permeable membrane surface will be one of the determinants of albumin loss by convection, such HDF treatment may reduce protein loss into the dialysate. To examine this assumption, we alternately repeated short and rapid fore- and backfiltrations (push/pull HDF) through a protein-permeable membrane, each less than 1 second in duration and at each filtration volume of 15 ml, where a pyrogen-free dialysate was supplied. The present results indicated that the albumin amount lost by push/pull HDF was approximately one-third of that by conventional HDF. Nevertheless, the reduction rates of β2- microglobulin and myoglobin were significantly greater by push/pull HDF than by conventional HDF.

本文言語English
ページ(範囲)432-435
ページ数4
ジャーナルKidney International
50
2
DOI
出版ステータスPublished - 1996
外部発表はい

All Science Journal Classification (ASJC) codes

  • Nephrology

フィンガープリント 「Alternate repetition of short fore- and backfiltrations reduces convective albumin loss」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル