Alternative splicing of the erythropoietin receptor gene correlates with erythroid differentiation in rat hematopoietic and leukemic cells

Masayuki Fujita, Rei Takahashi, Kazuhiro Kitada, Rei Watanabe, Sohei Kitazawa, Faramarz Ashoori, Ping Liang, Hideyuki Saya, Tadao Serikawa, Sakan Maeda

研究成果: Article査読

10 被引用数 (Scopus)

抄録

An alternative splicing of the rat erythropoietin receptor (EpoR) gene; was identified in normal and erythroleukemia cells. A 105 bp insert was found at a region corresponding to the extracellular domain of EpoR. The alternative transcript was translated to a soluble EpoR (EpoR-S) expressed in spleen, bone marrow, and cultured erythroleukemia cells in addition to the full-length EpoR (EpoR-F). One of the rat erythroleukemia sublines, K4DT, which partially lost erythroid phenotypes and manifested monocyte/macrophage characteristics also lacked EpoR-S expression. Thus, expression of EpoR-S may play an important role in differentiation of rat erythroid cells.

本文言語English
ページ(範囲)47-55
ページ数9
ジャーナルCancer Letters
112
1
DOI
出版ステータスPublished - 15-01-1997
外部発表はい

All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 癌研究

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