Altitude-Induced Pulmonary Hypertension on One-Day Rapid Ascent of Mount Fuji: Incidence and Therapeutic Effects of Sildenafil

Masatsugu Iwase, Yoshihiro Itou, Kayoko Takada, Kenji Shiino, Yasuchika Kato, Yukio Ozaki

研究成果: Article

4 引用 (Scopus)

抄録

Aims: Exposure to high altitudes especially with rapid ascent may induce hypoxic pulmonary vasoconstriction (HPV) and pulmonary hypertension (PH) possibly leading to life-threatening high-altitude pulmonary edema (HAPE). The aim of the study was to evaluate the incidence of PH on a 1-day rapid ascent up Mount Fuji (3775 m) in recreational climbers and also to determine the effectiveness of sildenafil for this rapid ascent-induced PH as measured by echocardiography. Methods and results: Twenty-five subjects who climbed Mount Fuji showed significantly increased pulmonary artery systolic pressure (PASP) from 22.3 ± 5.3 mmHg at sea level to 29.4 ± 8.7 mmHg at 3775 m. Five subjects showed PASP >35 mmHg (35.6–46.2 mmHg, average 42.0 ± 3.9 mmHg) and took oral sildenafil 50 mg after which PASP decreased significantly to 24.5 ± 4.6 mmHg (18.7–31.0 mmHg) after 30 minutes. Conclusions: One-day rapid ascent of Mount Fuji may induce mild-to-moderate PH and intervention with sildenafil can reduce this PH, suggesting that the therapeutic use of sildenafil would be more reasonable for the relatively infrequent occurrence of altitude-induced PH than its prophylactic use.

元の言語English
ページ(範囲)838-843
ページ数6
ジャーナルEchocardiography
33
発行部数6
DOI
出版物ステータスPublished - 01-06-2016

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Therapeutic Uses
Pulmonary Hypertension
Incidence
Pulmonary Artery
Blood Pressure
Pulmonary Edema
Vasoconstriction
Oceans and Seas
Echocardiography
Sildenafil Citrate
Lung

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

これを引用

Iwase, Masatsugu ; Itou, Yoshihiro ; Takada, Kayoko ; Shiino, Kenji ; Kato, Yasuchika ; Ozaki, Yukio. / Altitude-Induced Pulmonary Hypertension on One-Day Rapid Ascent of Mount Fuji : Incidence and Therapeutic Effects of Sildenafil. :: Echocardiography. 2016 ; 巻 33, 番号 6. pp. 838-843.
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abstract = "Aims: Exposure to high altitudes especially with rapid ascent may induce hypoxic pulmonary vasoconstriction (HPV) and pulmonary hypertension (PH) possibly leading to life-threatening high-altitude pulmonary edema (HAPE). The aim of the study was to evaluate the incidence of PH on a 1-day rapid ascent up Mount Fuji (3775 m) in recreational climbers and also to determine the effectiveness of sildenafil for this rapid ascent-induced PH as measured by echocardiography. Methods and results: Twenty-five subjects who climbed Mount Fuji showed significantly increased pulmonary artery systolic pressure (PASP) from 22.3 ± 5.3 mmHg at sea level to 29.4 ± 8.7 mmHg at 3775 m. Five subjects showed PASP >35 mmHg (35.6–46.2 mmHg, average 42.0 ± 3.9 mmHg) and took oral sildenafil 50 mg after which PASP decreased significantly to 24.5 ± 4.6 mmHg (18.7–31.0 mmHg) after 30 minutes. Conclusions: One-day rapid ascent of Mount Fuji may induce mild-to-moderate PH and intervention with sildenafil can reduce this PH, suggesting that the therapeutic use of sildenafil would be more reasonable for the relatively infrequent occurrence of altitude-induced PH than its prophylactic use.",
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Altitude-Induced Pulmonary Hypertension on One-Day Rapid Ascent of Mount Fuji : Incidence and Therapeutic Effects of Sildenafil. / Iwase, Masatsugu; Itou, Yoshihiro; Takada, Kayoko; Shiino, Kenji; Kato, Yasuchika; Ozaki, Yukio.

:: Echocardiography, 巻 33, 番号 6, 01.06.2016, p. 838-843.

研究成果: Article

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T2 - Incidence and Therapeutic Effects of Sildenafil

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AU - Itou, Yoshihiro

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AU - Shiino, Kenji

AU - Kato, Yasuchika

AU - Ozaki, Yukio

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Y1 - 2016/6/1

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