Amyloid β-peptide induces cholinergic dysfunction and cognitive deficits: A minireview

Manh Hung Tran, Kiyofumi Yamada, Toshitaka Nabeshima

研究成果: ジャーナルへの寄稿総説査読

60 被引用数 (Scopus)

抄録

Amyloid β-peptide (Aβ) plays a critical role in the development of Alzheimer's disease (AD). Much progress has been made in understanding this age-related neurodegenerative disorder, thus an insight into the cellular actions of Aβ and resulting functional consequences may contribute to preventive and therapeutic approaches for AD. In this review, recent evidence of Aβ-induced brain dysfunction, particularly of cholinergic impairment and memory deficits is summarized. Moreover, proposed mechanisms for Aβ-induced neurotoxicity such as oxidative stress, ion-channel formation, and Aβ-receptor interaction are discussed.

本文言語英語
ページ(範囲)1271-1283
ページ数13
ジャーナルPeptides
23
7
DOI
出版ステータス出版済み - 2002
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生化学
  • 生理学
  • 内分泌学
  • 細胞および分子神経科学

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