Amyloid β-peptide induces cholinergic dysfunction and cognitive deficits: A minireview

Manh Hung Tran, Kiyofumi Yamada, Toshitaka Nabeshima

研究成果: Review article

52 引用 (Scopus)

抜粋

Amyloid β-peptide (Aβ) plays a critical role in the development of Alzheimer's disease (AD). Much progress has been made in understanding this age-related neurodegenerative disorder, thus an insight into the cellular actions of Aβ and resulting functional consequences may contribute to preventive and therapeutic approaches for AD. In this review, recent evidence of Aβ-induced brain dysfunction, particularly of cholinergic impairment and memory deficits is summarized. Moreover, proposed mechanisms for Aβ-induced neurotoxicity such as oxidative stress, ion-channel formation, and Aβ-receptor interaction are discussed.

元の言語English
ページ(範囲)1271-1283
ページ数13
ジャーナルPeptides
23
発行部数7
DOI
出版物ステータスPublished - 01-01-2002
外部発表Yes

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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