Amyloid βprotein precursors with kunitz‐type inhibitor domains and acetyl‐cholinesterase in cerebrospinal fluid from patients with dementia of the Alzheimer type

K. Urakami, K. Takahashi, H. Saito, A. Okada, S. Nakamura, S. Tanaka, N. Kitaguchi, Y. Tokushima, S. Yamamoto

研究成果: Article査読

12 被引用数 (Scopus)

抄録

We used the ELISA to measure the concentration of amyloid protein precursor with Kunitz type trypsin inhibitor domains (APPI) in CSF of dementia of the Alzheimer type (DAT) and examined the correlation of APPI with acetylcholinesterase (AChE) and somatostatin (SRIF). We found the APPI concentration in CSF of DAT to be significantly elevated compared with that of multi‐infarct dementia and controls. We could significantly correlate APPI with AChE, but not correlate APPI with SRIF. The present results suggest that measurement of CSF APPI levels may be useful for diagnosis of DAT and the change of APPI may closely be associated with abnormality of acetylcholine system in DAT that has been reported.

本文言語English
ページ(範囲)343-346
ページ数4
ジャーナルActa Neurologica Scandinavica
85
5
DOI
出版ステータスPublished - 05-1992

All Science Journal Classification (ASJC) codes

  • 神経学
  • 臨床神経学

フィンガープリント

「Amyloid βprotein precursors with kunitz‐type inhibitor domains and acetyl‐cholinesterase in cerebrospinal fluid from patients with dementia of the Alzheimer type」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル