Amyloid Beta Protein Precursor with Kunitz-Type Protease Inhibitor Domains (APPI) in Cerebrospinal Fluid and APPI mRNAs in Cultured Skin Fibroblasts of Patients with Alzheimer's Disease

Katsuya Urakami, Akitsugu Okada, Kazuro Takahashi, Kousaku Ohno, Nobuya Kitaguchi, Seigo Tanaka, Shigenobu Nakamura

研究成果: Article査読

5 被引用数 (Scopus)

抄録

Urakami, K., Okada, A., Ohno, K., Kitaguchi, N., Tanaka, S., Nakamura, S. and Takahashi, K. Amyloid Beta Protein Precursor with Kunitz-Type Protease Inhibitor Domains (APPI) in Cerebrospinal Fluid and APPI mRNAs in Cultured Skin Fibroblasts of Patients with Alzheimer's Disease. Tohoku J. Exp. Med., 1994, 174 (3), 199-207 We studied amyloid beta protein precursor with Kunitz-type protease ihibitor domains (APPI) concentration in cerebrospinal fluid (CSF) and APPI mRNA in skin fibroblast in Alzheimer's disease (AD). The subjects consisted of AD, cerebrovascular dementia (VD) and age-matched controls. We measured the APPI concentration in the CSF by the trypsin antibody sandwich ELISA. APPI mRNA was examined by the RT-PCR teqchnique. The CSF APPI concentration in AD was significantly higher than that of VD and controls. The CSF APPI concentration in AD was high in the initial stage of dementia and decreased during the course. The expression of APPI mRNA in skin fibroblasts in AD was also significantly higher than that of VD and controls. These results suggest that measurements of APPI levels in CSF and APPI mRNA in skin fibroblasts may be useful for early diagnosis of AD. amyloid beta protein precursor with Kunitz-type protease inhibitor domains; Alzheimer's disease; cerebrospinal fluid; skin fibroblast; longitudinal study.

本文言語English
ページ(範囲)199-207
ページ数9
ジャーナルTohoku Journal of Experimental Medicine
174
3
DOI
出版ステータスPublished - 1994

All Science Journal Classification (ASJC) codes

  • 生化学、遺伝学、分子生物学(全般)

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