An analysis of behavioral and genetic risk factors for chemotherapy-induced nausea and vomiting in Japanese subjects

Naoki Mukoyama, Akira Yoshimi, Aya Goto, Haruka Kotani, Kazuhiro Ishikawa, Noriko Miyazaki, Masayuki Miyazaki, Kiyofumi Yamada, Fumitaka Kikkawa, Yoshinori Hasegawa, Norio Ozaki, Yukihiro Noda

研究成果: ジャーナルへの寄稿学術論文査読

12 被引用数 (Scopus)

抄録

There are individual differences in the frequency of chemotherapy-induced nausea and vomiting (CINV) in cancer patients. We investigated the individual variability in susceptibility to CINV with focus on both behavioral factors and genetic factors in Japanese cancer patients. We performed a prospective study to investigate the association between patient attributes (backgrounds and habits as well as gene polymorphisms) and anorexia, nausea, or vomiting in 55 Japanese cancer patients undergoing chemotherapy at Nagoya University Hospital. We found that gender (female), use of non-steroidal anti-inflammatory drugs, susceptibility to motion sickness, and anxiety were associated with the frequency of CINV. Gene polymorphisms of rs1076560 (dopamine D2 receptor gene), rs6766410 (serotonin 5-HT3C receptor gene) and rs4680 (catechol-Omethyltransferase gene) were also associated. Our data suggest that these attributes may thus be risk factors for CINV. Our results provide novel information that can be used to predict the incidence of CINV in Japanese patients undergoing chemotherapy; this can help provide a substantial improvement in supportive care for patients with different types of cancer.

本文言語英語
ページ(範囲)1852-1858
ページ数7
ジャーナルBiological and Pharmaceutical Bulletin
39
11
DOI
出版ステータス出版済み - 2016
外部発表はい

All Science Journal Classification (ASJC) codes

  • 薬理学
  • 薬科学

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