An autopsy case of cryptococcal meningoencephalitis with AIDS: Correspondence between MRI and pathological findings of basal ganglia and cerebellum

Toshitaka Umemura, Mikio Hirayama, Yoshiki Niimi, Katsuji Matsui, Yoshio Hashizume

研究成果: Article

4 引用 (Scopus)

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We reported a 71-year-old male who showed subacute progression in cognitive decline and gait disturbance. Cystic lesions in the basal ganglia and a high signal in the right cerebellar hemishere were detected respectively on MRI fluid-attenuated inversion recovery (FLAIR) image and diffusion weighted image (DWI) taken at 7 days after admission to our hospital. Dilatation of the Virchow-Robin space and fresh cerebellar infarction were suspected. Since an examination of cerebrospinal fluid (CSF) did not reveal any significant features, diagnosis of this patient proved very difficult. His cellular immunodeficiency was detected by bone marrow aspiration, so he was diagnosed as suffering from acquired immunodeficiency syndrome (AIDS). Six months after onset, the patient died from sepsis and respiratory failure. Pathological findings revealed multiple cryptococcus in the cystic lesions of the basal ganglia and cerebellum. There was little infiltration of inflammatory cells while pathological findings did not demonstrate any AIDS encephalopathy or vascular disorders. We speculated that subacute progression in cognitive decline and gait disturbance had been caused by cryptococcal meningoencephalitis and secondary normal pressure hydrocephalus (NPH). Cryptococcal meningoencephalitis in patients with AIDS is often accompanied by normal CSF as a result of cellular immunodeficiency, therefore diagnosis needs to be very careful. Particular attention needs to be paid to the existence of cryptococcal meningoencephalitis when patients show subacute progression in cognitive decline and cystic lesions in the basal ganglia present themselves on MRI.

元の言語English
ページ(範囲)623-627
ページ数5
ジャーナルBrain and Nerve
59
発行部数6
出版物ステータスPublished - 01-06-2007
外部発表Yes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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