Analyses of peripheral blood mononuclear cells in operational tolerance after pediatric living donor liver transplantation

Ying Li, Takaaki Koshiba, Atsushi Yoshizawa, Yukihide Yonekawa, Kosuke Masuda, Atsushi Ito, Mikiko Ueda, Takahide Mori, Hiroshi Kawamoto, Yoshimasa Tanaka, Shimon Sakaguchi, Nagahiro Minato, Kathryn J. Wood, Koichi Tanaka

研究成果: Article査読

210 被引用数 (Scopus)

抄録

Operational tolerance (graft acceptance in an immuno-suppression (IS)-free environment) after living-donor liver transplantation (LDLT) could occur by our elective protocol in some patients. There is, nevertheless, no reliable parameter to monitor patients who may discontinue IS without a risk of rejection. To identify such parameters, we systemically phenotyped peripheral blood mononuclear cells from operationally tolerant patients. An increase was observed in the frequency of CD4+CD25high+ cells, B cells and Vδ1/Vδ2 γδ-cells ratio in operationally tolerant patients (Gr-tol; n = 12), compared with those from age-matched volunteers (Gr-vol; n = 24) or patients on IS (Gr-IS; n = 19). The frequency of NK cells was decreased in Gr-tol, compared with those in Gr-IS or Gr-vol. The frequency of NKT cells was decreased after LDLT, compared with that in Gr-vol. Although the contribution of those subsets to the tolerant state remains elusive, the results may provide important clues for reliable indicators of tolerance after LDLT.

本文言語English
ページ(範囲)2118-2125
ページ数8
ジャーナルAmerican Journal of Transplantation
4
12
DOI
出版ステータスPublished - 12-2004
外部発表はい

All Science Journal Classification (ASJC) codes

  • 免疫アレルギー学
  • 移植
  • 薬理学(医学)

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