Analysis of the association between galectin-3 concentration in tears and the severity of dry eye disease: A case-control study

Miki Hata-Mizuno, Yuichi Uchino, Miki Uchino, Shigeto Shimmura, Yoko Ogawa, Kazuo Tsubota, Kazuno Negishi

研究成果: ジャーナルへの寄稿学術論文査読

1 被引用数 (Scopus)

抄録

This study aimed to investigate the relationship between the severity of dry eye disease (DED) and galectin-3 concentration (gal-3) and its cleavage (gal-3C) in tear fluid. Twenty-eight DED patients and 14 controls were recruited at Keio University Hospital. The lissamine green conjunctival staining (LG) score, fluorescein corneal staining (FL) score, tear film break-up time (TBUT), Schirmer’s test, and ocular symptoms questionnaire score (dry eye questionnaire score, DEQS) were evaluated. Furthermore, the correlation between these parameters and the concentrations of gal-3 in tears (ng/µg) and the detection rate of gal-3C (%) were analyzed. Gal-3 concentration in tears was positively correlated with the LG score (R = 0.60, p < 0.01), FL score (R = 0.49, p < 0.01), and DEQS (R = 0.45, p < 0.01), and negatively correlated with the TBUT score (R = −0.40, p <0.01) and Schirmer’s I value (R = −0.36, p < 0.01). The detection rate of gal-3C in tears was significantly associated with the severity of DED, especially with the LG (p < 0.01) and FL (p < 0.01) scores. Therefore, the concentration of gal-3 and the detection rate of gal-3C in tears had a significant relationship with the severity of ocular surface barrier disruption.

本文言語英語
論文番号66
ジャーナルJournal of Clinical Medicine
11
1
DOI
出版ステータス出版済み - 01-01-2022
外部発表はい

All Science Journal Classification (ASJC) codes

  • 医学一般

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