TY - CHAP
T1 - Angiogenesis in response to hypoxia
AU - Ozawa, Y.
AU - Tsubota, K.
AU - Okano, H.
N1 - Publisher Copyright:
© 2010 Elsevier Ltd. All rights reserved.
PY - 2010/1/1
Y1 - 2010/1/1
N2 - Angiogenesis is regulated by the balance of angiogenic and anti-angiogenic factors through multiple pathways. In this article, we focus on hypoxia that regulates angiogenic factors. Two potent angiogenic factors - vascular endothelial growth factor (VEGF) and erythropoietin (Epo) - are regulated by transcription factors called hypoxia-inducible factors (HIFs). Several pathways that regulate the HIFs under hypoxic conditions are described. Then, we review the mechanisms, that is, involvement of VEGF and Epo, in pathological angiogenesis in the retina and describe supporting experimental data obtained from model animals, in addition to human clinical data. We also discuss how hypoxia regulates vascular development in the retina.
AB - Angiogenesis is regulated by the balance of angiogenic and anti-angiogenic factors through multiple pathways. In this article, we focus on hypoxia that regulates angiogenic factors. Two potent angiogenic factors - vascular endothelial growth factor (VEGF) and erythropoietin (Epo) - are regulated by transcription factors called hypoxia-inducible factors (HIFs). Several pathways that regulate the HIFs under hypoxic conditions are described. Then, we review the mechanisms, that is, involvement of VEGF and Epo, in pathological angiogenesis in the retina and describe supporting experimental data obtained from model animals, in addition to human clinical data. We also discuss how hypoxia regulates vascular development in the retina.
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U2 - 10.1016/B978-0-12-374203-2.00122-6
DO - 10.1016/B978-0-12-374203-2.00122-6
M3 - Chapter
AN - SCOPUS:85079822323
SN - 9780123741981
SP - 88
EP - 92
BT - Encyclopedia of the Eye
PB - Elsevier
ER -