Animal models of Alzheimer's disease and evaluation of anti-dementia drugs

Kiyofumi Yamada, Toshitaka Nabeshima

研究成果: Review article査読

159 被引用数 (Scopus)

抄録

Alzheimer's disease (AD) is the most common cause of progressive decline of cognitive function in aged humans, and is characterized by the presence of numerous senile plaques and neurofibrillary tangles accompanied by neuronal loss. Some, but not all, of the neuropathological alterations and cognitive impairment in AD can be reproduced genetically and pharmacologically in animals. It should be possible to discover novel drugs that slow the progress or alleviate the clinical symptoms of AD by using these animal models. We review the recent progress in the development of animal models of AD and discuss how to use these model animals to evaluate novel anti-dementia drugs.

本文言語English
ページ(範囲)93-113
ページ数21
ジャーナルPharmacology and Therapeutics
88
2
DOI
出版ステータスPublished - 2000
外部発表はい

All Science Journal Classification (ASJC) codes

  • 薬理学
  • 薬理学(医学)

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