Animal models of Alzheimer's disease and evaluation of anti-dementia drugs

Kiyofumi Yamada, Toshitaka Nabeshima

研究成果: Review article

143 引用 (Scopus)

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Alzheimer's disease (AD) is the most common cause of progressive decline of cognitive function in aged humans, and is characterized by the presence of numerous senile plaques and neurofibrillary tangles accompanied by neuronal loss. Some, but not all, of the neuropathological alterations and cognitive impairment in AD can be reproduced genetically and pharmacologically in animals. It should be possible to discover novel drugs that slow the progress or alleviate the clinical symptoms of AD by using these animal models. We review the recent progress in the development of animal models of AD and discuss how to use these model animals to evaluate novel anti-dementia drugs.

元の言語English
ページ(範囲)93-113
ページ数21
ジャーナルPharmacology and Therapeutics
88
発行部数2
DOI
出版物ステータスPublished - 01-01-2000
外部発表Yes

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All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

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