Anti-hepatitis B surface immunoglobulin reduction in early postoperative period after liver transplantation in hepatitis B virus-positive patients

Masatoshi Ishigami, Yasuharu Onishi, Takashi Ito, Yoshiaki Katano, Akihiro Ito, Yoshiki Hirooka, Tetsuya Kiuchi, Hidemi Goto

研究成果: ジャーナルへの寄稿学術論文査読

6 被引用数 (Scopus)

抄録

Aim: We investigated a protocol that lowered the necessary dose of anti-hepatitis B surface immunoglobulin (HBIg) with frequent monitoring of hepatitis B surface antigen (HBsAg) and antibody (HBsAb) levels in the early post-transplant period. Methods: Fifteen hepatitis B virus (HBV)-positive patients were studied. We administered a nucleoside analog from the preoperative period, high dose HBIg was used intraoperatively (200IU/kg in the patients who weighed less than 50kg, and 10000IU in those who weighed more than or equal to 50kg) and was continued every day (5000-10000IU/day). Thereafter, HBIg was administered to keep the target trough titers. We evaluated the effectiveness and safety of this protocol for preventing HBV reactivation. Results: The average use of HBIg during the first three postoperative months (POM) was 27.9±9.6Kilo International Units. The average cost was $US11800 in the first three postoperative months, compared with other previously reported protocols (about $20000-40000). HBV reactivation was detected in only one patient (6.7%) during the median follow up of 64months (range: 12-86months). Conclusions: The present protocol for HBIg administration, which used frequent monitoring of HBsAg and HBsAb levels to determine the minimum required dose, was both safe and effective, and contributed to overall cost saving after liver transplantation.

本文言語英語
ページ(範囲)1189-1198
ページ数10
ジャーナルHepatology Research
41
12
DOI
出版ステータス出版済み - 12-2011
外部発表はい

All Science Journal Classification (ASJC) codes

  • 肝臓学
  • 感染症

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