Anticancer Effects of Adriamycin-Loaded Hydroxyapatite Implants Determined in a Swarm Rat Chondrosarcoma Model

Keiko Yamamura; Takashi Osada; Toshitaka Nabeshima; Hisashi Iwata; Toshihisa Yotsuyanagi

doi:10.1254/jjp.65.289

Anticancer Effects of Adriamycin-Loaded Hydroxyapatite Implants Determined in a Swarm Rat Chondrosarcoma Model

Keiko Yamamura
, Takashi Osada
, Toshitaka Nabeshima
, Hisashi Iwata
, Toshihisa Yotsuyanagi

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

8 被引用数 (Scopus)

抄録

We investigated the antitumor effects of adriamycin (ADR)-loaded hydroxyapatite (HAP) beads in a Swarm rat chondrosarcoma model. When one ADR-loaded HAP bead (ADR: 0.8 mg/bead) was implanted into the central portion of a rat bearing tumor, the ADR-loaded HAP beads showed good therapeutic effects, increasing the life span (ILS) by 90%. Significantly, leukopenia and diarrhea were not observed. These results suggest that HAP delivery offers an interesting and a potentially effective method.

本文言語	英語
ページ（範囲）	289-291
ページ数	3
ジャーナル	Japanese Journal of Pharmacology
巻	65
号	3
DOI	https://doi.org/10.1254/jjp.65.289
出版ステータス	出版済み - 1994
外部発表	はい

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薬理学

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abstract = "We investigated the antitumor effects of adriamycin (ADR)-loaded hydroxyapatite (HAP) beads in a Swarm rat chondrosarcoma model. When one ADR-loaded HAP bead (ADR: 0.8 mg/bead) was implanted into the central portion of a rat bearing tumor, the ADR-loaded HAP beads showed good therapeutic effects, increasing the life span (ILS) by 90\%. Significantly, leukopenia and diarrhea were not observed. These results suggest that HAP delivery offers an interesting and a potentially effective method.",

author = "Keiko Yamamura and Takashi Osada and Toshitaka Nabeshima and Hisashi Iwata and Toshihisa Yotsuyanagi",

year = "1994",

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AU - Yamamura, Keiko

AU - Osada, Takashi

AU - Nabeshima, Toshitaka

AU - Iwata, Hisashi

AU - Yotsuyanagi, Toshihisa

PY - 1994

Y1 - 1994

N2 - We investigated the antitumor effects of adriamycin (ADR)-loaded hydroxyapatite (HAP) beads in a Swarm rat chondrosarcoma model. When one ADR-loaded HAP bead (ADR: 0.8 mg/bead) was implanted into the central portion of a rat bearing tumor, the ADR-loaded HAP beads showed good therapeutic effects, increasing the life span (ILS) by 90%. Significantly, leukopenia and diarrhea were not observed. These results suggest that HAP delivery offers an interesting and a potentially effective method.

AB - We investigated the antitumor effects of adriamycin (ADR)-loaded hydroxyapatite (HAP) beads in a Swarm rat chondrosarcoma model. When one ADR-loaded HAP bead (ADR: 0.8 mg/bead) was implanted into the central portion of a rat bearing tumor, the ADR-loaded HAP beads showed good therapeutic effects, increasing the life span (ILS) by 90%. Significantly, leukopenia and diarrhea were not observed. These results suggest that HAP delivery offers an interesting and a potentially effective method.

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UR - https://www.scopus.com/pages/publications/0028061236#tab=citedBy

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VL - 65

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EP - 291

JO - Japanese Journal of Pharmacology

JF - Japanese Journal of Pharmacology

IS - 3

ER -

Anticancer Effects of Adriamycin-Loaded Hydroxyapatite Implants Determined in a Swarm Rat Chondrosarcoma Model

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