Antiepileptic medications in autism spectrum disorder: A systematic review and meta-analysis

Tomoya Hirota, Jeremy Veenstra-Vanderweele, Eric Hollander, Taro Kishi

研究成果: Review article査読

43 被引用数 (Scopus)

抄録

Electroencephalogram-recorded epileptiform activity is common in children with autism spectrum disorder (ASD), even without clinical seizures. A systematic literature search identified 7 randomized, placebo-controlled trials of antiepileptic drugs (AEDs) in ASD (total n = 171), including three of valproate, and one each of lamotrigine, levetiracetam, and topiramate. Meta-analysis revealed no significant difference between medication and placebo in four studies targeting irritability/agitation and three studies investigating global improvement, although limitations include lack of power and different medications with diverse actions. Across all seven studies, there was no significant difference in discontinuation rate between two groups. AEDs do not appear to have a large effect size to treat behavioral symptoms in ASD, but further research is needed, particularly in the subgroup of patients with epileptiform abnormalities.

本文言語English
ページ(範囲)948-957
ページ数10
ジャーナルJournal of Autism and Developmental Disorders
44
4
DOI
出版ステータスPublished - 04-2014

All Science Journal Classification (ASJC) codes

  • 発達心理学および教育心理学

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