TY - JOUR
T1 - Antigen expression associated with lymph node metastasis in gastric adenocarcinomas
AU - Wang, Shi‐Nong ‐N
AU - Miyauchi, Motohiro
AU - Koshikawa, Nobuko
AU - Maruyama, Koshi
AU - Kubota, Tetsuo
AU - Miura, Keiji
AU - Kurosawa, Yoshikazu
AU - Awaya, Akira
AU - Kanai, Yoshiyuki
PY - 1994/12
Y1 - 1994/12
N2 - A total of 100 gastric adenocarcinomas, comprising 50 cases with lymph node metastasis and 50 cases without lymph node metastasis, were examined for immunohistochemical reactivity with the monoclonal antibody to urokinase‐type plasminogen activator (u‐PA), Lex related 4C9 antigen, Jun, or to nucleobindin (Nuc). In tumors with lymph node metastasis, 41 (82%) were positive for u‐PA and 28 (56%) were positive for Nuc. In tumors without lymph node metastasis, 26 (52%) were positive for u‐PA and five (10%) were positive for Nuc. The percentage of cases positive for u‐PA or Nuc was significantly higher in tumors with lymph node metastasis than that in tumors without lymph node metastasis (P < 0.01). The expression of u‐PA was found to be significantly correlated with that of Nuc (P < 0.001), mode of infiltrative growth (P < 0.05), depth of invasion (P < 0.01), and grade of lymphatic invasion (P < 0.01). However, the expression of Nuc was found to be significantly correlated with the expression of Jun (P< 0.05), depth of invasion (P < 0.01), and grade of lymphatic invasion (P < 0.001). These results suggest that immunohistochemical examination for the expression of u‐PA and Nuc in tumor cells may help evaluate the potential of adenocarcinomas of the stomach for lymph node metastasis.
AB - A total of 100 gastric adenocarcinomas, comprising 50 cases with lymph node metastasis and 50 cases without lymph node metastasis, were examined for immunohistochemical reactivity with the monoclonal antibody to urokinase‐type plasminogen activator (u‐PA), Lex related 4C9 antigen, Jun, or to nucleobindin (Nuc). In tumors with lymph node metastasis, 41 (82%) were positive for u‐PA and 28 (56%) were positive for Nuc. In tumors without lymph node metastasis, 26 (52%) were positive for u‐PA and five (10%) were positive for Nuc. The percentage of cases positive for u‐PA or Nuc was significantly higher in tumors with lymph node metastasis than that in tumors without lymph node metastasis (P < 0.01). The expression of u‐PA was found to be significantly correlated with that of Nuc (P < 0.001), mode of infiltrative growth (P < 0.05), depth of invasion (P < 0.01), and grade of lymphatic invasion (P < 0.01). However, the expression of Nuc was found to be significantly correlated with the expression of Jun (P< 0.05), depth of invasion (P < 0.01), and grade of lymphatic invasion (P < 0.001). These results suggest that immunohistochemical examination for the expression of u‐PA and Nuc in tumor cells may help evaluate the potential of adenocarcinomas of the stomach for lymph node metastasis.
KW - adenocarcinoma
KW - metastasis
KW - nucleobindin
KW - stomach
KW - urokinase‐type plasminogen activator
UR - https://www.scopus.com/pages/publications/0027971923
UR - https://www.scopus.com/pages/publications/0027971923#tab=citedBy
U2 - 10.1111/j.1440-1827.1994.tb01682.x
DO - 10.1111/j.1440-1827.1994.tb01682.x
M3 - Article
C2 - 7866567
AN - SCOPUS:0027971923
SN - 1320-5463
VL - 44
SP - 844
EP - 849
JO - Pathology International
JF - Pathology International
IS - 12
ER -