Antinociceptive action of tizanidine in mice and rats

Tsutomu Kameyama, Toshitaka Nabeshima, Akira Sugimoto, Kiyoshi Matsuno, Shigeyuki Yamada

研究成果: Article査読

41 被引用数 (Scopus)

抄録

The antinociceptive action of tizanidine [5-chloro-(2-imidazolin-2-yl-amino)-2,1,3-benzothiadiazole], a centrally acting muscle relaxant, was evaluated after subcutaneous or peroral administration in mice and rats. Tizanidine strongly inhibited the writhing response induced by acetic acid, phenyl-p-benzoquinone and acetylcholine in mice, and its potency was found to be greater than that of morphine. Tizanidine showed antinociceptive action like morphine not only in tail pressure and electrical stimulation tests in mice but also in tail-flick tests in mice and rats. The antinociceptive action of tizanidine was unaffected by pretreatment with naloxone. These findings suggest that tizanidine develops relatively strong antinociceptive action by a nonopioid mechanism.

本文言語English
ページ(範囲)93-96
ページ数4
ジャーナルNaunyn-Schmiedeberg's Archives of Pharmacology
330
2
DOI
出版ステータスPublished - 01-08-1985
外部発表はい

All Science Journal Classification (ASJC) codes

  • 薬理学

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