Antitumor effect of combination chemotherapy with TNP-470 and CDDP on intracranial tumor transplanted in rats. Histological changes of intratumoral tissue

N. Isobe, T. Uozumi, K. Kurisu, K. Kawamoto, K. Sudo, K. Sugiyama, S. Monden, T. Nishi, K. Harada, T. Inoue, T. Sadatomo, S. Hama

研究成果: Article査読

抄録

Previously we reported antitumor effect of TNP-470 on intracranial tumor, which is 9-L gliosarcoma, transplanted in rats. This time we examined antitumor effect of the combination with TNP-470 and CDDP, compared with the administration of the single agent. TNP-470 made the ischemic changes in tumor tissue, and CDDP brought about coagulation necrosis. The combination chemotherapy elongated the survival periods of the transplanted rats without severe side effects. Therefore this treatment was considered to be effective for the treatment of glial tumors. But we should look into the administration dose and methods of antitumor agents.

本文言語English
ページ(範囲)440-441
ページ数2
ジャーナルBiotherapy
9
3
出版ステータスPublished - 1995
外部発表はい

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

フィンガープリント 「Antitumor effect of combination chemotherapy with TNP-470 and CDDP on intracranial tumor transplanted in rats. Histological changes of intratumoral tissue」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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