Antitumor effect of suberoylanilide hydroxamic acid and topotecan in renal cancer cells

Akinori Sato, Takako Asano, Akio Horiguchi, Keiichi Ito, Makoto Sumitomo, Tomohiko Asano

研究成果: Article査読

12 被引用数 (Scopus)

抄録

The treatment modality for advanced renal cancer is limited. The development of novel systemic therapies has long been waited for. Suberoylanilide hydroxamic acid (SAHA) is one of the most potent histone deacetylase (HDAC) inhibitors, which are promising novel anticancer agents. SAHA has already been tested in phase II clinical trials; however, its effectiveness has been found to be limited. Recently, the combination of SAHA and topoisomerase I inhibitor, topotecan, was shown to be effective, but this treatment strategy has not been tested in renal cancer cells. In the present study, we found that the combination of SAHA and topotecan effectively inhibited the growth of renal cancer cells by suppressing the expression of cyclin-dependent kinase (CDK) 4 and cyclin D1, and promoting retinoblastoma protein (Rb) dephosphorylation. Furthermore, the combination therapy was found to inhibit both the function and expression of HDACs, which may be one of the main mechanisms of the combination therapy. To the best of our knowledge, this is the first report that has revealed the combined beneficial effect of SAHA and topotecan on renal cancer cells. Combining SAHA and topotecan is thus a promising approach to the treatment of renal cancer.

本文言語English
ページ(範囲)217-233
ページ数17
ジャーナルOncology Research
19
5
DOI
出版ステータスPublished - 19-08-2011
外部発表はい

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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