Antitumor effect of triphenylethylene derivative (TAT‐59) against human breast carcinoma xenografts in nude mice

Jun‐Ichi ‐I Koh, Tetsuro Kubota, Fumiki Asanuma, Yoshinori Yamada, Eiji Kawamura, Yoichiro Hosoda, Mitsumasa Hashimoto, Osami Yamamoto, Shoji Sakai, Koutaro Maeda, Eiichi Shiina

研究成果: Article査読

13 被引用数 (Scopus)

抄録

The antitumor activity of a newly synthesized triphenylethylene derivative {(E)‐4‐[1‐4‐[2‐(dimethylamino)ethoxy‐phenyl]‐2‐(4‐isopropyl)phenyl‐1‐butenyl] phenyl monophosphate} (TAT‐59) was investigated against human breast carcinoma xenografts in nude mice with reference to the changes of hormone receptors. Five strains (MCF‐7, Br‐10, R‐27, ZR‐75–1, and T‐61) used for the experiments possessed cytosol estrogen receptor (ER), and their growth was estradiol dependent. Five mg of TAT‐59 and tamoxifen citrate (TAM) per kg were administered p.o. daily except Sunday. TAT‐59 showed a positive antitumor effect against MCF‐7 and R‐27, whereas TAM was effective on MCF‐7, and their adverse effects detected by mortality rate, body weight loss, and spleen weight loss were similar to each other. The reduction of ER and production of progesterone receptor (PgR) after the treatment with TAT‐59 were more potent than after TAM, suggesting that TAT‐59 exerts its antitumor effect through binding to ER. These findings suggest that TAT‐59 might merit use in clinical trials with breast cancers. © 1992 Wiley‐Liss, Inc.

本文言語English
ページ(範囲)254-258
ページ数5
ジャーナルJournal of Surgical Oncology
51
4
DOI
出版ステータスPublished - 12-1992
外部発表はい

All Science Journal Classification (ASJC) codes

  • 外科
  • 腫瘍学

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